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EBI PDBe PDBeView

PDBe Entry: 1lrt view

CRYSTAL STRUCTURE OF TERNARY COMPLEX OF TRITRICHOMONAS FOETUS INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE: STRUCTURAL CHARACTERIZATION OF NAD+ SITE IN MICROBIAL ENZYME
Summary
Header OXIDOREDUCTASEsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.2 Å, R-factor: 21.8%, Free R-factor: 24.6%, Spacegroup: P 21 21 21
Released 07/07/2003, deposition: 15/05/2002, last revision: 24/02/2009
Authors Gan, L.search; Petsko, G.A.search; Hedstrom, L.search
Primary citation Crystal structure of a ternary complex of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: NAD+ orients the active site loop for catalysis
BIOCHEMISTRYsearch vol:41, pag:13309-13317 (2003) [PubMed ID 12403633 ]search
Keywords ternary complexsearch, alpha-beta barrelsearch, flexible loopsearch, flapsearch, OXIDOREDUCTASEsearch
EC 1.1.1.205 ExPASy BRENDA search (A B C D)
Organism Tritrichomonas foetus 5724search(A B C D)
UniProt Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (IMP dehydrogenase) (IMPDH) (IMPD) P50097search (A B C D)
Solvent A, B, C, D
Related entries 1ak5
Polymers
Id Name Type UniProt Residues Observed
A, B, C, D INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE Protein P50097 (IMDH_TRIFO)search
 376 90%
Heterogens
Id Name Ligands
A INOSINE-5'-MONOPHOSPHATE BOG search
A, B, C, D POTASSIUM ION K search
A, B, C, D INOSINIC ACID IMP search
A, B, C, D BETA-METHYLENE-THIAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE TAD search
A, C, B, D 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL TRS search
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