1lqk Summary

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High Resolution Structure of Fosfomycin Resistance Protein A (FosA)

The structure was published by Rife, C.L., Pharris, R.E., Newcomer, M.E., and Armstrong, R.N., in 2002 in a paper entitled "Crystal structure of a genomically encoded fosfomycin resistance protein (FosA) at 1.19 A resolution by MAD phasing off the L-III edge of Tl(+)" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.35 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of probable Fosfomycin Resistance Protein.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A probable Fosfomycin Resistance Protein Q9I4K6 (1-135) (FOSA_PSEAE)search Pseudomonas aeruginosa PAO1search 100% 135 99%
B probable Fosfomycin Resistance Protein Q9I4K6 (1-135) (FOSA_PSEAE)search Pseudomonas aeruginosa PAO1search 100% 135 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9I4K6 (1 - 135) probable Fosfomycin Resistance Protein Pseudomonas aeruginosa

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (Q9I4K6) Antibiotic resistance proteinssearch 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1search PF12681: Glyoxalase-like domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q9I4K6) metabolic processsearch response to antibioticsearch metal ion bindingsearch glutathione transferase activitysearch transferase activitysearch cytoplasmsearch

Chain InterPro annotation
A, B Glyoxalase-like domainsearch Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenasesearch