1lph Summary

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LYS(B28)PRO(B29)-HUMAN INSULIN

There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Ciszak, E., Beals, J.M., Frank, B.H., Baker, J.C., Carter, N.D., and Smith, G.D., in 1995 in a paper entitled "Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1995.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INSULIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INSULIN P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
C INSULIN P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
B INSULIN P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%
D INSULIN P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01308 (90 - 110) INSULIN Homo sapiens

Chain Structural classification (SCOP) Sequence family (Pfam)
A, C (P01308) Insulin-likesearch PF00049: Insulin/IGF/Relaxin familysearch
B, D (P01308) Insulin-likesearch PF00049: Insulin/IGF/Relaxin familysearch

Chain ID Molecular function (GO) Cellular component (GO)
A, C (P01308) hormone activitysearch extracellular regionsearch
B, D (P01308) hormone activitysearch extracellular regionsearch

Chain InterPro annotation
A, C Insulin-likesearch Insulin, conserved sitesearch
B, D Insulinsearch Insulin-likesearch