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LYS(B28)PRO(B29)-HUMAN INSULIN

X-ray diffraction
2.3Å resolution
PDB entry 1lph coloured by chain, front view.
PDB entry 1lph coloured by chain, side view.
PDB entry 1lph coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero dimer (preferred)
hetero dodecamer
hetero tetramer
hetero hexamer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Insulin complex
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Multimeric state: hetero dimer
Accessible surface area: 3519.7 Å2
Buried surface area: 1655.74 Å2
Dissociation area: 793.33 Å2
Dissociation energy (ΔGdiss): 9.14 kcal/mol
Dissociation entropy (TΔSdiss): 8.06 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134182
Complex Portal ID: CPX-943
Assembly 2 (preferred)
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Assembly Name: Insulin complex
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Multimeric state: hetero dimer
Accessible surface area: 3877.39 Å2
Buried surface area: 1740.26 Å2
Dissociation area: 655.59 Å2
Dissociation energy (ΔGdiss): 3.54 kcal/mol
Dissociation entropy (TΔSdiss): 8.1 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134182
Complex Portal ID: CPX-943
Assembly 3
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Assembly Name: Insulin A chain
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Multimeric state: hetero dodecamer
Accessible surface area: 13438.22 Å2
Buried surface area: 18319.43 Å2
Dissociation area: 125.7 Å2
Dissociation energy (ΔGdiss): 31.94 kcal/mol
Dissociation entropy (TΔSdiss): 1.12 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134235
Assembly 4
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Assembly Name: Insulin A chain
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Multimeric state: hetero dodecamer
Accessible surface area: 18495.44 Å2
Buried surface area: 13262.21 Å2
Dissociation area: 767.7 Å2
Dissociation energy (ΔGdiss): 3.35 kcal/mol
Dissociation entropy (TΔSdiss): 11.38 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134235
Assembly 5
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Assembly Name: Insulin A chain
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Multimeric state: hetero dodecamer
Accessible surface area: 22687.75 Å2
Buried surface area: 9069.9 Å2
Dissociation area: 438.18 Å2
Dissociation energy (ΔGdiss): 1.16 kcal/mol
Dissociation entropy (TΔSdiss): 10.91 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134235
Assembly 6
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Assembly Name: Insulin A chain
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Multimeric state: hetero tetramer
Accessible surface area: 6510.6 Å2
Buried surface area: 4281.44 Å2
Dissociation area: 1,963.6 Å2
Dissociation energy (ΔGdiss): 10.22 kcal/mol
Dissociation entropy (TΔSdiss): 25.35 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134210
Assembly 7
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Assembly Name: Insulin A chain
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Multimeric state: hetero tetramer
Accessible surface area: 6057.65 Å2
Buried surface area: 4735.45 Å2
Dissociation area: 670.51 Å2
Dissociation energy (ΔGdiss): 2.2 kcal/mol
Dissociation entropy (TΔSdiss): 9.29 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134210
Assembly 8
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Assembly Name: Insulin A chain
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Multimeric state: hetero hexamer
Accessible surface area: 10018.94 Å2
Buried surface area: 6405.17 Å2
Dissociation area: 2,256.15 Å2
Dissociation energy (ΔGdiss): 13.27 kcal/mol
Dissociation entropy (TΔSdiss): 25.97 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134224
Assembly 9
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Assembly Name: Insulin A chain
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Multimeric state: hetero hexamer
Accessible surface area: 10011.45 Å2
Buried surface area: 5322.09 Å2
Dissociation area: 279.31 Å2
Dissociation energy (ΔGdiss): 21.85 kcal/mol
Dissociation entropy (TΔSdiss): 18.95 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134224

Macromolecules

Insulin A chain
Chains: A, C
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:
SCOP: Insulin-like
Insulin A chain in PDB entry 1lph, assembly 2, front view.
Insulin A chain in PDB entry 1lph, assembly 2, side view.
Insulin A chain in PDB entry 1lph, assembly 2, top view.
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Insulin B chain
Chains: B, D
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
SCOP: Insulin-like
Insulin B chain in PDB entry 1lph, assembly 2, front view.
Insulin B chain in PDB entry 1lph, assembly 2, side view.
Insulin B chain in PDB entry 1lph, assembly 2, top view.
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