1lkq Summary

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NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-GLY, VAL-A3-GLY, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES

The structure was published by Hua, Q.X., Chu, Y.C., Jia, W., et al., Wang, R.Y., Katsoyannis, P.G., and Weiss, M.A., in 2002 in a paper entitled "Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely INSULIN.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A INSULIN P01308 (90-110) (INS_HUMAN)search Homo sapienssearch 100% 21 100%
B INSULIN P01308 (25-54) (INS_HUMAN)search Homo sapienssearch 100% 30 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P01308 (90 - 110) INSULIN

Chain Structural classification (SCOP) Sequence family (Pfam)
A (P01308) Insulin-likesearch PF00049: Insulin/IGF/Relaxin familysearch
B (P01308) Insulin-likesearch PF00049: Insulin/IGF/Relaxin familysearch
Chain InterPro annotation
A Insulin-likesearch Insulin, conserved sitesearch
B Insulin-likesearch