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EBI PDBe PDBeView

PDBe Entry: 1ljt view

Crystal Structure of Macrophage Migration Inhibitory Factor complexed with (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole-acetic acid methyl ester (ISO-1)
Summary
Header IMMUNE SYSTEMsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.0 Å, R-factor: 23.7%, Free R-factor: 26.2%, Spacegroup: P 31 2 1
Released 27/11/2002, deposition: 22/04/2002, last revision: 24/02/2009
Authors Lubetsky, J.B.search; Dios, A.search; Han, J.search; Aljabari, B.search; Ruzsicska, B.search; Mitchell, R.search; Lolis, E.search; Al-Abed, Y.search
Primary citation The Tautomerase Active Site of Macrophage Migration Inhibitory factor is a Potential Target for Discovery of Novel Anti-inflammatory Agents
J.BIOL.CHEM.search vol:277, pag:24976-24982 (2002) [PubMed ID 11997397 ]search
Keywords protein-inhibitor complexsearch, IMMUNE SYSTEMsearch
EC 5.3.2.1 ExPASy BRENDA search 5.3.3.12 ExPASy BRENDA search (A B C)
Organism Homo sapiens(human) 9606search(A B C)
UniProt Macrophage migration inhibitory factor (EC 5.3.2.1) (MIF) (Phenylpyruvate tautomerase) (Glycosylation-inhibiting factor) (GIF) P14174search (A B C)
Solvent A, B, C
Polymers
Id Name Type UniProt Residues Observed
A, B, C Macrophage migration inhibitory factor Protein P14174 (MIF_HUMAN)search
 114 100%
Heterogens
Id Name Ligands
A, B, C 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER HDI search
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