› 1lj5

X-ray diffraction
1.8Å resolution

1.8A Resolution Structure of Latent Plasminogen Activator Inhibitor-1(PAI-1)

Released:
DOI: 10.2210/pdb1lj5/pdb
PDB entry 1lj5 coloured by chain, front view.
PDB entry 1lj5 coloured by chain, side view.
PDB entry 1lj5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Stein PE, Baek K

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasminogen activator inhibitor 1 Chain: A
Molecule details ›
Chain: A
Length: 379 amino acids
Theoretical weight: 42.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05121 (Residues: 24-402; Coverage: 100%)
Gene names: PAI1, PLANH1, SERPINE1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand DMS 4 x DMS
Ligand ACY 1 x ACY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: C2
Unit cell:
a: 156.574Å b: 46.885Å c: 63.048Å
α: 90° β: 106.54° γ: 90°
R-values:
R R work R free
0.198 0.198 0.241
Expression system: Escherichia coli BL21(DE3)

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