Function and Biology

Crystal structure of Q363F/R402A mutant flavocytochrome c3

Source organism: Shewanella frigidimarina
Biochemical function: metal ion binding
Biological process: anaerobic electron transport chain
Cellular component: periplasmic space

EC 1.3.5.1: Succinate dehydrogenase (quinone)

Reaction catalysed:
Succinate + a quinone = fumarate + a quinol
Systematic name:
Succinate:quinone oxidoreductase
Alternative Name(s):
  • Complex II
  • SDH
  • Succinate dehydrogenase (ubiquinone)
  • Succinate dehydrogenase complex
  • Succinate:ubiquinone oxidoreductase
  • Succinic dehydrogenase

Sequence families

Pfam Protein families (Pfam)
PF00890
Domain description: FAD binding domain
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 1lj1 contains 2 copies of Pfam domain PF00890 (FAD binding domain) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.

PF14537
Domain description: Cytochrome c3
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 1lj1 contains 2 copies of Pfam domain PF14537 (Cytochrome c3) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR027477
Domain description: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily
Occurring in:
  1. Fumarate reductase flavoprotein subunit
IPR036188
Domain description: FAD/NAD(P)-binding domain superfamily
Occurring in:
  1. Fumarate reductase flavoprotein subunit
IPR010960
Domain description: Flavocytochrome c
Occurring in:
  1. Fumarate reductase flavoprotein subunit
IPR003953
Domain description: FAD-dependent oxidoreductase 2, FAD binding domain
Occurring in:
  1. Fumarate reductase flavoprotein subunit
IPR013087
Domain description: Zinc finger C2H2-type
Occurring in:
  1. Fumarate reductase flavoprotein subunit
IPR012286
Domain description: Tetrahaem cytochrome domain
Occurring in:
  1. Fumarate reductase flavoprotein subunit
IPR036280
Domain description: Multiheme cytochrome superfamily
Occurring in:
  1. Fumarate reductase flavoprotein subunit

Structure domains

CATH CATH domains
3.50.50.60
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: FAD/NAD(P)-binding domain
Homology: FAD/NAD(P)-binding domain
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 1lj1 contains 2 copies of CATH domain 3.50.50.60 (FAD/NAD(P)-binding domain) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.
3.90.700.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Flavocytochrome C3; Chain A, domain 1
Homology: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 1lj1 contains 2 copies of CATH domain 3.90.700.10 (Flavocytochrome C3; Chain A, domain 1) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.
1.10.1130.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Flavocytochrome C3; Chain A, domain 2
Homology: Flavocytochrome C3; Chain A
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 1lj1 contains 2 copies of CATH domain 1.10.1130.10 (Flavocytochrome C3; Chain A, domain 2) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.
SCOP SCOP annotations
51934
Class: Alpha and beta proteins (a/b)
Fold: FAD/NAD(P)-binding domain
Superfamily: FAD/NAD(P)-binding domain
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 1lj1 contains 2 copies of SCOP domain 51934 (Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.
56426
Class: Alpha and beta proteins (a+b)
Fold: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
Superfamily: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 1lj1 contains 2 copies of SCOP domain 56426 (Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.
48711
Class: All alpha proteins
Fold: Multiheme cytochromes
Superfamily: Multiheme cytochromes
Occurring in:
  1. Fumarate reductase flavoprotein subunit
The deposited structure of PDB entry 1lj1 contains 2 copies of SCOP domain 48711 (Di-heme elbow motif) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.