1lhd Summary

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HUMAN ALPHA-THROMBIN COMPLEXED WITH AC-(D)PHE-PRO-BOROLYS-OH

The structure was published by Weber, P.C., Lee, S.L., Lewandowski, F.A., Schadt, M.C., Chang, C.W., and Kettner, C.A., in 1995 in a paper entitled "Kinetic and crystallographic studies of thrombin with Ac-(D)Phe-Pro-boroArg-OH and its lysine, amidine, homolysine, and ornithine analogs." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.35 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely ALPHA-THROMBIN and HIRUDIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
L ALPHA-THROMBIN P00734 (328-363) (THRB_HUMAN)search Homo sapienssearch 93% 36 72%
H ALPHA-THROMBIN P00734 (364-622) (THRB_HUMAN)search Homo sapienssearch 93% 259 96%
I HIRUDIN Not available
Hirudo medicinalissearch Not available 12 58%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00734 (328 - 363) ALPHA-THROMBIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
L (P00734) Eukaryotic proteasessearch PF09396: Thrombin light chainsearch
H (P00734) Eukaryotic proteasessearch Trypsin-like serine proteasessearch PF00089: Trypsinsearch
I

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
L (P00734) proteolysissearch blood coagulationsearch serine-type endopeptidase activitysearch extracellular regionsearch
H (P00734) blood coagulationsearch proteolysissearch serine-type endopeptidase activitysearch calcium ion bindingsearch catalytic activitysearch

Chain InterPro annotation
L Thrombin light chainsearch
H Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Prothrombin/thrombinsearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch
I