1lgc Summary

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INTERACTION OF A LEGUME LECTIN WITH THE N2 FRAGMENT OF HUMAN LACTOTRANSFERRIN OR WITH THE ISOLATED BIANTENNARY GLYCOPEPTIDE: ROLE OF THE FUCOSE MOIETY

The structure was published by Bourne, Y., Mazurier, J., Legrand, D., et al., Montreuil, J., Spik, G., and Cambillau, C., in 1994 in a paper entitled "Structures of a legume lectin complexed with the human lactotransferrin N2 fragment, and with an isolated biantennary glycopeptide: role of the fucose moiety." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely LEGUME ISOLECTIN II (ALPHA CHAIN), DIPEPTIDE, and LEGUME ISOLECTIN II (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A LEGUME ISOLECTIN II (ALPHA CHAIN) P04122 (1-181) (LECB_LATOC)search Lathyrus ochrussearch 100% 181 100%
C LEGUME ISOLECTIN II (ALPHA CHAIN) P04122 (1-181) (LECB_LATOC)search Lathyrus ochrussearch 100% 181 100%
E LEGUME ISOLECTIN II (ALPHA CHAIN) P04122 (1-181) (LECB_LATOC)search Lathyrus ochrussearch 100% 181 100%
H DIPEPTIDE Not available
Not available Not available 2 100%
I DIPEPTIDE Not available
Not available Not available 2 100%
J DIPEPTIDE Not available
Not available Not available 2 100%
B LEGUME ISOLECTIN II (BETA CHAIN) P12307 (1-53) (LEC2_LATOC)search Lathyrus ochrussearch 100% 53 96%
D LEGUME ISOLECTIN II (BETA CHAIN) P12307 (1-53) (LEC2_LATOC)search Lathyrus ochrussearch 100% 53 96%
F LEGUME ISOLECTIN II (BETA CHAIN) P12307 (1-53) (LEC2_LATOC)search Lathyrus ochrussearch 100% 53 96%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P04122 (1 - 181) LEGUME ISOLECTIN II (ALPHA CHAIN) Lathyrus ochrus
P12307 (1 - 53) LEGUME ISOLECTIN II (BETA CHAIN)

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E (P04122) Legume lectinssearch Jelly Rollssearch PF00139: Legume lectin domainsearch
H, I, J
B, D, F (P12307) Legume lectinssearch PF00139: Legume lectin domainsearch

Chain ID Molecular function (GO)
A, C, E (P04122) carbohydrate bindingsearch metal ion bindingsearch mannose bindingsearch
B, D, F (P12307) carbohydrate bindingsearch mannose bindingsearch

Chain InterPro annotation
A, C, E Legume lectin domainsearch search Concanavalin A-like lectin/glucanase domainsearch Legume lectin, beta chain, Mn/Ca-binding sitesearch
H, I, J
B, D, F Legume lectin, alpha chain, conserved sitesearch Legume lectin domainsearch search Concanavalin A-like lectin/glucanase domainsearch