1lfz Summary

pdbe.org/1lfz
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OXY HEMOGLOBIN (25% METHANOL)

The structure was published by Biswal, B.K. and Vijayan, M., in 2002 in a paper entitled "Structures of human oxy- and deoxyhaemoglobin at different levels of humidity: variability in the T state." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P69905) iron ion bindingsearch protein bindingsearch heme bindingsearch oxygen transporter activitysearch metal ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen bindingsearch small molecule metabolic processsearch positive regulation of cell deathsearch oxygen transportsearch bicarbonate transportsearch protein heterooligomerizationsearch oxidation-reduction processsearch response to hydrogen peroxidesearch transportsearch hydrogen peroxide catabolic processsearch extracellular regionsearch hemoglobin complexsearch cytosolsearch membranesearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch blood microparticlesearch cytosolic small ribosomal subunitsearch
B (P68871) oxygen bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch protein bindingsearch metal ion bindingsearch iron ion bindingsearch heme bindingsearch peroxidase activitysearch hemoglobin bindingsearch bicarbonate transportsearch renal absorptionsearch positive regulation of cell deathsearch platelet aggregationsearch response to hydrogen peroxidesearch oxygen transportsearch protein heterooligomerizationsearch blood coagulationsearch nitric oxide transportsearch oxidation-reduction processsearch transportsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood pressuresearch regulation of blood vessel sizesearch haptoglobin-hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch cytosolsearch blood microparticlesearch hemoglobin complexsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch