1lfz Summary

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OXY HEMOGLOBIN (25% METHANOL)

The structure was published by Biswal, B.K. and Vijayan, M., in 2002 in a paper entitled "Structures of human oxy- and deoxyhaemoglobin at different levels of humidity: variability in the T state." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P69905) iron ion bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch haptoglobin bindingsearch oxygen bindingsearch heme bindingsearch metal ion bindingsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch cytosolsearch blood microparticlesearch hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch membranesearch oxygen transportsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch positive regulation of cell deathsearch transportsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch oxidation-reduction processsearch
B (P68871) heme bindingsearch protein bindingsearch oxygen bindingsearch iron ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch cytosolsearch extracellular regionsearch extracellular vesicular exosomesearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch oxygen transportsearch oxidation-reduction processsearch bicarbonate transportsearch regulation of blood pressuresearch platelet aggregationsearch renal absorptionsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch blood coagulationsearch regulation of blood vessel sizesearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch nitric oxide transportsearch transportsearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch