1lfy Summary

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OXY HEMOGLOBIN (84% RELATIVE HUMIDITY)

The structure was published by Biswal, B.K. and Vijayan, M., in 2002 in a paper entitled "Structures of human oxy- and deoxyhaemoglobin at different levels of humidity: variability in the T state." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.3 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P69905) extracellular vesicular exosomesearch blood microparticlesearch endocytic vesicle lumensearch extracellular regionsearch cytosolsearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch membranesearch protein bindingsearch oxygen transporter activitysearch iron ion bindingsearch oxygen bindingsearch haptoglobin bindingsearch heme bindingsearch peroxidase activitysearch metal ion bindingsearch protein heterooligomerizationsearch transportsearch bicarbonate transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch response to hydrogen peroxidesearch oxygen transportsearch positive regulation of cell deathsearch
B (P68871) extracellular regionsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch iron ion bindingsearch protein bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch peroxidase activitysearch heme bindingsearch oxygen bindingsearch oxygen transporter activitysearch metal ion bindingsearch bicarbonate transportsearch protein heterooligomerizationsearch small molecule metabolic processsearch oxygen transportsearch response to hydrogen peroxidesearch platelet aggregationsearch positive regulation of nitric oxide biosynthetic processsearch renal absorptionsearch regulation of blood vessel sizesearch nitric oxide transportsearch regulation of blood pressuresearch positive regulation of cell deathsearch transportsearch oxidation-reduction processsearch blood coagulationsearch hydrogen peroxide catabolic processsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch