1lfv Summary

pdbe.org/1lfv
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OXY HEMOGLOBIN (88% RELATIVE HUMIDITY)

The structure was published by Biswal, B.K. and Vijayan, M., in 2002 in a paper entitled "Structures of human oxy- and deoxyhaemoglobin at different levels of humidity: variability in the T state." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P69905) oxygen bindingsearch heme bindingsearch protein bindingsearch iron ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch hemoglobin complexsearch cytosolic small ribosomal subunitsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch cytosolsearch extracellular exosomesearch membranesearch blood microparticlesearch endocytic vesicle lumensearch oxygen transportsearch oxidation-reduction processsearch receptor-mediated endocytosissearch bicarbonate transportsearch positive regulation of cell deathsearch protein heterooligomerizationsearch small molecule metabolic processsearch transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch
B (P68871) heme bindingsearch iron ion bindingsearch protein bindingsearch peroxidase activitysearch oxygen bindingsearch oxygen transporter activitysearch metal ion bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch extracellular regionsearch hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch cytosolsearch extracellular exosomesearch haptoglobin-hemoglobin complexsearch oxygen transportsearch bicarbonate transportsearch oxidation-reduction processsearch positive regulation of cell deathsearch small molecule metabolic processsearch regulation of blood pressuresearch renal absorptionsearch receptor-mediated endocytosissearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch platelet aggregationsearch blood coagulationsearch nitric oxide transportsearch hydrogen peroxide catabolic processsearch transportsearch regulation of blood vessel sizesearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch