› 1lfi

X-ray diffraction
2.1Å resolution

METAL SUBSTITUTION IN TRANSFERRINS: THE CRYSTAL STRUCTURE OF HUMAN COPPER-LACTOFERRIN AT 2.1 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1lfi/pdb
PDB entry 1lfi coloured by chain, front view.
PDB entry 1lfi coloured by chain, side view.
PDB entry 1lfi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Metal substitution in transferrins: the crystal structure of human copper-lactoferrin at 2.1-A resolution.
Smith CA, Anderson BF, Baker HM, Baker EN
Biochemistry 31 4527-33 (1992)
PMID: 1581307

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136228 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Lactotransferrin Chain: A
Molecule details ›
Chain: A
Length: 691 amino acids
Theoretical weight: 76.25 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02788 (Residues: 20-710; Coverage: 100%)
Gene names: GIG12, LF, LTF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand CU 2 x CU
Ligand CO3 2 x CO3
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 155.9Å b: 97Å c: 56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 not available not available
Expression system: Not provided

Quick links

Citations

6 review citations

A structural perspective on lactoferrin function.
Baker et al. (2012)
5 more

4 mentions without citation

The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor.
Hu et al. (2021)
3 more