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CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS ACTIVATOR MKK3B

The structure was published by Chang, C.I., Xu, B.E., Akella, R., Cobb, M.H., and Goldsmith, E.J., in 2002 in a paper entitled "Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely MITOGEN-ACTIVATED PROTEIN KINASE 14 and MAP kinase kinase 3b.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MITOGEN-ACTIVATED PROTEIN KINASE 14 P47811 (1-360) (MK14_MOUSE)search Mus musculussearch 97% 360 95%
B MAP kinase kinase 3b O09110 (16-32) (MP2K3_MOUSE)search Mus musculussearch < 90% 18 44%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P47811 (1 - 360) MITOGEN-ACTIVATED PROTEIN KINASE 14 Mus musculus
O09110 (16 - 32) MAP kinase kinase 3b

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P47811) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
B

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P47811) protein phosphorylationsearch vascular endothelial growth factor receptor signaling pathwaysearch signal transduction in response to DNA damagesearch response to muramyl dipeptidesearch angiogenesissearch lipopolysaccharide-mediated signaling pathwaysearch fatty acid oxidationsearch response to lipopolysaccharidesearch regulation of transcription, DNA-templatedsearch stress-induced premature senescencesearch peptidyl-serine phosphorylationsearch transcription, DNA-templatedsearch intracellular signal transductionsearch positive regulation of myoblast differentiationsearch cellular response to lipopolysaccharidesearch myoblast differentiation involved in skeletal muscle regenerationsearch positive regulation of reactive oxygen species metabolic processsearch response to stresssearch regulation of transcription from RNA polymerase II promotersearch cartilage condensationsearch glucose metabolic processsearch striated muscle cell differentiationsearch chondrocyte differentiationsearch positive regulation of myoblast fusionsearch cell morphogenesissearch p38MAPK cascadesearch positive regulation of erythrocyte differentiationsearch skeletal muscle tissue developmentsearch cellular response to DNA damage stimulussearch cellular response to ionizing radiationsearch positive regulation of protein import into nucleussearch phosphorylationsearch DNA damage checkpointsearch cellular response to vascular endothelial growth factor stimulussearch positive regulation of myotube differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of canonical Wnt signaling pathwaysearch osteoclast differentiationsearch apoptotic processsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch kinase activitysearch MAP kinase activitysearch protein bindingsearch NFAT protein bindingsearch protein serine/threonine kinase activitysearch transferase activitysearch nucleotide bindingsearch nucleussearch cytosolsearch cytoplasmsearch cellsearch spindle polesearch mitochondrionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch
B