1lek Summary

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Crystal Structure of H-2Kbm3 bound to dEV8

The structure was published by Luz, J.G., Huang, M., Garcia, K.C., et al., Apostolopoulos, V., Teyton, L., and Wilson, I.A., in 2002 in a paper entitled "Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, K-B ALPHA CHAIN, Beta-2-microglobulin, and dEV8.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, K-B ALPHA CHAIN P01901 (22-295) (HA1B_MOUSE)search Mus musculussearch 100% 274 100%
B Beta-2-microglobulin P01887 (21-119) (B2MG_MOUSE)search Mus musculussearch 99% 99 100%
P dEV8 Q62425 (61-68) (NDUA4_MOUSE)search Mus musculussearch < 90% 8 100%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P01901 (22 - 295) H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, K-B ALPHA CHAIN Mus musculus
P01887 (21 - 119) Beta-2-microglobulin Mus musculus
Q62425 (61 - 68) dEV8

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P01901) C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Murine Class I Major Histocompatibility Complex, H2-DB, subunit A, domain 1search, Immunoglobulinssearch PF00129: Class I Histocompatibility antigen, domains alpha 1 and 2search, PF07654: Immunoglobulin C1-set domainsearch
B (P01887) C1 set domains (antibody constant domain-like)search Immunoglobulinssearch PF07654: Immunoglobulin C1-set domainsearch
P NADH-ubiquinone reductase complex 1 MLRQ subunitsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P01901) immune responsesearch antigen processing and presentationsearch positive regulation of T cell mediated cytotoxicitysearch antigen processing and presentation of peptide antigen via MHC class Isearch MHC class I protein complexsearch membranesearch peptide antigen bindingsearch
B (P01887) response to molecule of bacterial originsearch positive regulation of T cell mediated cytotoxicitysearch response to drugsearch protein refoldingsearch immune system processsearch response to cadmium ionsearch T cell differentiation in thymussearch antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependentsearch cellular defense responsesearch retina homeostasissearch antigen processing and presentation of peptide antigen via MHC class Isearch phagocytic vesicle membranesearch extracellular spacesearch plasma membranesearch extracellular vesicular exosomesearch cytoplasmsearch extracellular regionsearch external side of plasma membranesearch MHC class I protein complexsearch Golgi apparatussearch identical protein bindingsearch protein bindingsearch

Chain InterPro annotation
A MHC class I alpha chain, alpha1 alpha2 domainssearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC class I-like antigen recognitionsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class I alpha chainsearch
B Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin-like foldsearch
P