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EBI PDBe PDBeView

PDBe Entry: 1lei view

The kB DNA sequence from the HLV-LTR functions as an allosteric regulator of HIV transcription
Summary
Header TRANSCRIPTION/DNAsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.7 Å, R-factor: 25.0%, Free R-factor: 28.4%, Spacegroup: C 2 2 2
Released 15/04/2003, deposition: 09/04/2002, last revision: 24/02/2009
Authors Chen-Park, F.search; Huang, D.B.search; Ghosh, G.search
Primary citation The kB DNA sequence from the HIV Long Terminal Repeat functions as an allosteric regulator of HIV transcription
J.BIOL.CHEM.search vol:277, pag:24701-24708 (2002) [PubMed ID 11970949 ]search
Keywords transcription factorsearch, NF-kB/DNA complexsearch, crystal structuresearch, TRANSCRIPTION/DNA COMPLEXsearch
Organism Mus musculus(house mouse) 10090search(A B)
UniProt Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) Q04207search (A)
Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (NF-kappa-B1 p84/NF-kappa-B1 p98) [Contains: Nuclear factor NF-kappa-B p50 subunit] P25799search (B)
Solvent A, B
Related entries 1vkx
Polymers
Id Name Type UniProt Residues Observed
C 5'-D(*CP*TP*CP*AP*GP*GP*GP*AP*AP*AP*GP*TP*AP*CP*AP*GP*A)-3' DNA
17 100%
D 5'-D(*TP*CP*TP*GP*5ITP*AP*CP*5ITP*5ITP*5ITP*CP*CP*CP*TP*GP*AP*G)-3' DNA
17 100%
A NUCLEAR FACTOR NF-KAPPA-B P65 SUBUNIT Protein Q04207 (TF65_MOUSE)search
 274 99%
B NUCLEAR FACTOR NF-KAPPA-B P50 SUBUNIT Protein P25799 (NFKB1_MOUSE)search
 313 99%
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