1ldk Summary


Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex

The structure was published by Zheng, N., Schulman, B.A., Song, L., et al., Conaway, J.W., Harper, J.W., and Pavletich, N.P., in 2002 in a paper entitled "Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This entry contains 8 copies of 5 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CULLIN HOMOLOG Q13616 (15-410) (CUL1_HUMAN)search Homo sapienssearch 98% 396 90%
B CULLIN HOMOLOG Q13616 (411-776) (CUL1_HUMAN)search Homo sapienssearch 98% 366 100%
C ring-box protein 1 P62877 (19-108) (RBX1_HUMAN)search Homo sapienssearch 90% 90 97%
D CYCLIN A/CDK2-ASSOCIATED PROTEIN P19 P63208 (2-140) (SKP1_HUMAN)search Homo sapienssearch 98% 133 88%
E SKP2-like protein type gamma Q13309 (97-137) (SKP2_HUMAN)search Homo sapienssearch < 90% 41 100%

This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
Q13616 (15 - 410) CULLIN HOMOLOG Homo sapiens
P62877 (19 - 108) ring-box protein 1 Homo sapiens
P63208 (2 - 140) CYCLIN A/CDK2-ASSOCIATED PROTEIN P19 Homo sapiens
Q13309 (97 - 137) SKP2-like protein type gamma Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q13616) Cullin repeatsearch Cullin Repeatssearch PF00888: Cullin familysearch
B (Q13616) SCF ubiquitin ligase complex WHB domainsearch, Cullin homology domainsearch Cullin Repeatssearch, "winged helix" repressor DNA binding domainsearch PF00888: Cullin familysearch, PF10557: Cullin protein neddylation domainsearch
C (P62877) RING finger domain, C3HC4search Zinc/RING finger domain, C3HC4 (zinc finger)search PF12678: RING-H2 zinc fingersearch
D (P63208) Skp1 dimerisation domain-likesearch, BTB/POZ domainsearch Potassium Channel Kv1.1; Chain Asearch PF01466: Skp1 family, dimerisation domainsearch, PF03931: Skp1 family, tetramerisation domainsearch
E F-box domainsearch Monooxygenasesearch F-box-likesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q13616) ubiquitin protein ligase bindingsearch cullin-RING ubiquitin ligase complexsearch ubiquitin-dependent protein catabolic processsearch
B (Q13616) ubiquitin protein ligase bindingsearch cullin-RING ubiquitin ligase complexsearch ubiquitin-dependent protein catabolic processsearch
C (P62877) zinc ion bindingsearch
D (P63208) ubiquitin-dependent protein catabolic processsearch

Chain InterPro annotation
A Cullin, N-terminalsearch Cullin repeat-like-containing domainsearch
B Cullin, N-terminalsearch Winged helix-turn-helix DNA-binding domainsearch Cullin, conserved sitesearch Cullin homologysearch Cullin protein, neddylation domainsearch
C Zinc finger, RING-typesearch Zinc finger, RING/FYVE/PHD-typesearch Zinc finger, RING-H2-typesearch
D SKP1 componentsearch BTB/POZ foldsearch SKP1 component, dimerisationsearch SKP1 component, POZ domainsearch E3 ubiquitin ligase, SCF complex, Skp subunitsearch
E F-box domainsearch