1lcj Summary

pdbe.org/1lcj
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SH2 (SRC HOMOLOGY-2) DOMAIN OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 11 RESIDUE PHOSPHOTYROSYL PEPTIDE EPQPYEEIPIYL

The structure was published by Eck, M.J., Shoelson, S.E., and Harrison, S.C., in 1993 in a paper entitled "Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely P56==LCK== TYROSINE KINASE and PHOSPHOPEPTIDE EPQ(PHOSPHO)YEEIPIYL.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A P56==LCK== TYROSINE KINASE P06239 (119-226) (LCK_HUMAN)search Homo sapienssearch < 90% 109 95%
B PHOSPHOPEPTIDE EPQ(PHOSPHO)YEEIPIYL P03079 (321-331) (MT_POVHA)search Hamster polyomavirussearch < 90% 11 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P06239 (119 - 226) P56==LCK== TYROSINE KINASE Homo sapiens
P03079 (321 - 331) PHOSPHOPEPTIDE EPQ(PHOSPHO)YEEIPIYL

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
B
Chain InterPro annotation
A SH2 domainsearch
B