› 1lbb

X-ray diffraction
2.1Å resolution

Crystal structure of the GluR2 ligand binding domain mutant (S1S2J-N754D) in complex with kainate at 2.1 A resolution

Released:
DOI: 10.2210/pdb1lbb/pdb
PDB entry 1lbb coloured by chain, front view.
PDB entry 1lbb coloured by chain, side view.
PDB entry 1lbb coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanism of glutamate receptor desensitization.
Sun Y, Olson R, Horning M, Armstrong N, Mayer M, Gouaux E
Nature 417 245-53 (2002)
PMID: 12015593

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148604 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 29.22 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand KAI 1 x KAI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 43.99Å b: 63.27Å c: 46.51Å
α: 90° β: 92.25° γ: 90°
R-values:
R R work R free
0.201 0.201 0.26
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

90 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
89 more

2 mentions without citation

A role for extracellular Na+ in the channel gating of native and recombinant kainate receptors.
Paternain et al. (2003)
1 more