› 1lba

X-ray diffraction
2.2Å resolution

THE STRUCTURE OF BACTERIOPHAGE T7 LYSOZYME, A ZINC AMIDASE AND AN INHIBITOR OF T7 RNA POLYMERASE

Released:
DOI: 10.2210/pdb1lba/pdb
PDB entry 1lba coloured by chain, front view.
PDB entry 1lba coloured by chain, side view.
PDB entry 1lba coloured by chain, top view.
Source organism: Escherichia phage T7
Primary publication:
The structure of bacteriophage T7 lysozyme, a zinc amidase and an inhibitor of T7 RNA polymerase.
Cheng X, Zhang X, Pflugrath JW, Studier FW
Proc Natl Acad Sci U S A 91 4034-8 (1994)
PMID: 8171031

Function and Biology Details

Reaction catalysed: 
Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133591 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endolysin Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 16.34 KDa
Source organism: Escherichia phage T7
Expression system: Not provided
UniProt:
  • Canonical: P00806 (Residues: 7-151; Coverage: 96%)
Gene name: 3.5
Sequence domains: N-acetylmuramoyl-L-alanine amidase
Structure domains: Peptidoglycan recognition protein-like

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2221
Unit cell:
a: 46.5Å b: 62.5Å c: 110Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.19 not available
Expression system: Not provided

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Citations

16 review citations

The immune response of Drosophila.
Hoffmann JA. (2003)
15 more

9 mentions without citation

Protein binding site prediction using an empirical scoring function.
Liang et al. (2006)
8 more