1l9x Summary


Structure of gamma-Glutamyl Hydrolase

The structure was published by Li, H., Ryan, T.J., Chave, K.J., and Van Roey, P., in 2002 in a paper entitled "Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of gamma-glutamyl hydrolase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A gamma-glutamyl hydrolase Q92820 (25-318) (GGH_HUMAN)search Homo sapienssearch 100% 315 93%
B gamma-glutamyl hydrolase Q92820 (25-318) (GGH_HUMAN)search Homo sapienssearch 100% 315 93%
C gamma-glutamyl hydrolase Q92820 (25-318) (GGH_HUMAN)search Homo sapienssearch 100% 315 93%
D gamma-glutamyl hydrolase Q92820 (25-318) (GGH_HUMAN)search Homo sapienssearch 100% 315 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q92820 (25 - 318) gamma-glutamyl hydrolase Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q92820) Class I glutamine amidotransferases (GAT)search Rossmann foldsearch PF07722: Peptidase C26search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (Q92820) proteolysissearch glutamine metabolic processsearch response to zinc ionsearch response to drugsearch response to ethanolsearch response to insulinsearch omega peptidase activitysearch gamma-glutamyl-peptidase activitysearch catalytic activitysearch hydrolase activitysearch exopeptidase activitysearch extracellular vesicular exosomesearch lysosomesearch cytosolsearch melanosomesearch extracellular spacesearch extracellular regionsearch nucleussearch

Chain InterPro annotation
A, B, C, D Peptidase C26search Peptidase C26, gamma-glutamyl hydrolasesearch Class I glutamine amidotransferase-likesearch