1l7z Summary


Crystal structure of Ca2+/Calmodulin complexed with myristoylated CAP-23/NAP-22 peptide

The structure was published by Matsubara, M., Nakatsu, T., Kato, H., and Taniguchi, H., in 2004 in a paper entitled "Crystal structure of a myristoylated CAP-23/NAP-22 N-terminal domain complexed with Ca2+/calmodulin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CALMODULIN and CAP-23/NAP-22.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CALMODULIN P62158 (2-149) (CALM_HUMAN)search Homo sapienssearch 97% 148 95%
B CAP-23/NAP-22 Not available
Synthetic Not available 9 66%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62158 (2 - 149) CALMODULIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P62158) Calmodulin-likesearch EF-handsearch PF00036: EF handsearch, PF13499: EF-hand domain pairsearch, PF13833: EF-hand domain pairsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P62158) calcium ion bindingsearch protein bindingsearch ion channel bindingsearch thioesterase bindingsearch protein domain specific bindingsearch N-terminal myristoylation domain bindingsearch titin bindingsearch metal ion bindingsearch protein phosphatase activator activitysearch type 3 metabotropic glutamate receptor bindingsearch enzyme regulator activitysearch protein serine/threonine kinase activator activitysearch phosphatidylinositol 3-kinase bindingsearch protein kinase bindingsearch nitric-oxide synthase regulator activitysearch calcium-dependent protein bindingsearch phospholipase bindingsearch protein N-terminus bindingsearch nitric-oxide synthase bindingsearch adenylate cyclase bindingsearch plasma membranesearch cytosolsearch nucleussearch cytoplasmsearch spindlesearch spindle polesearch nucleoplasmsearch cytoskeletonsearch neuron projectionsearch extracellular regionsearch vesiclesearch extracellular vesicular exosomesearch growth conesearch spindle microtubulesearch centrosomesearch calcium channel complexsearch sarcomeresearch epidermal growth factor receptor signaling pathwaysearch synaptic transmissionsearch response to amphetaminesearch positive regulation of protein autophosphorylationsearch nitric oxide metabolic processsearch platelet activationsearch positive regulation of phosphoprotein phosphatase activitysearch regulation of cell communication by electrical coupling involved in cardiac conductionsearch regulation of nitric-oxide synthase activitysearch positive regulation of peptidyl-threonine phosphorylationsearch neurotrophin TRK receptor signaling pathwaysearch response to calcium ionsearch carbohydrate metabolic processsearch innate immune responsesearch phototransduction, visible lightsearch regulation of rhodopsin mediated signaling pathwaysearch regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumsearch negative regulation of peptidyl-threonine phosphorylationsearch regulation of high voltage-gated calcium channel activitysearch response to corticosteronesearch rhodopsin mediated signaling pathwaysearch glucose metabolic processsearch signal transductionsearch regulation of cardiac muscle contractionsearch positive regulation of nitric-oxide synthase activitysearch glycogen catabolic processsearch activation of phospholipase C activitysearch platelet degranulationsearch muscle contractionsearch positive regulation of protein serine/threonine kinase activitysearch regulation of cytokinesissearch activation of adenylate cyclase activitysearch positive regulation of cyclic-nucleotide phosphodiesterase activitysearch blood coagulationsearch regulation of ryanodine-sensitive calcium-release channel activitysearch calcium-mediated signalingsearch small molecule metabolic processsearch Fc-epsilon receptor signaling pathwaysearch G-protein coupled receptor signaling pathwaysearch regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionsearch negative regulation of ryanodine-sensitive calcium-release channel activitysearch positive regulation of cyclic nucleotide metabolic processsearch positive regulation of ryanodine-sensitive calcium-release channel activitysearch substantia nigra developmentsearch regulation of heart ratesearch detection of calcium ionsearch inositol phosphate metabolic processsearch membrane organizationsearch fibroblast growth factor receptor signaling pathwaysearch positive regulation of protein dephosphorylationsearch

Chain InterPro annotation
A EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch