1l7v Summary

pdbe.org/1l7v
spacer

Bacterial ABC Transporter Involved in B12 Uptake

The structure was published by Locher, K.P., Lee, A.T., and Rees, D.C., in 2002 in a paper entitled "The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely VITAMIN B12 TRANSPORT SYSTEM PERMEASE PROTEIN BTUC and Vitamin B12 transport ATP-binding protein btuD.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A VITAMIN B12 TRANSPORT SYSTEM PERMEASE PROTEIN BTUC P06609 (1-326) (BTUC_ECOLI)search Escherichia coli K-12search 100% 326 99%
B VITAMIN B12 TRANSPORT SYSTEM PERMEASE PROTEIN BTUC P06609 (1-326) (BTUC_ECOLI)search Escherichia coli K-12search 100% 326 99%
C Vitamin B12 transport ATP-binding protein btuD P06611 (1-249) (BTUD_ECOLI)search Escherichia coli K-12search 100% 249 92%
D Vitamin B12 transport ATP-binding protein btuD P06611 (1-249) (BTUD_ECOLI)search Escherichia coli K-12search 100% 249 92%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P06609 (1 - 326) VITAMIN B12 TRANSPORT SYSTEM PERMEASE PROTEIN BTUC Escherichia coli
P06611 (1 - 249) Vitamin B12 transport ATP-binding protein btuD Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P06609) ABC transporter involved in vitamin B12 uptake, BtuCsearch ABC transporter involved in vitamin B12 uptake, BtuCsearch PF01032: FecCD transport familysearch
C, D (P06611) ABC transporter ATPase domain-likesearch P-loop containing nucleotide triphosphate hydrolasessearch PF00005: ABC transportersearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P06609) membranesearch integral component of plasma membranesearch plasma membranesearch integral component of membranesearch ATP-binding cassette (ABC) transporter complexsearch cobalamin transportsearch vitamin transmembrane transportsearch transportsearch transporter activitysearch protein bindingsearch cobalamin transporter activitysearch cobalamin-transporting ATPase activitysearch
C, D (P06611) plasma membranesearch cytosolsearch extrinsic component of membranesearch extrinsic component of cytoplasmic side of plasma membranesearch ATP-binding cassette (ABC) transporter complexsearch membranesearch cobalamin transportsearch ATP catabolic processsearch metabolic processsearch vitamin transmembrane transportsearch transportsearch ATPase activitysearch ATP bindingsearch hydrolase activitysearch nucleotide bindingsearch cobalamin-transporting ATPase activitysearch protein bindingsearch

Chain InterPro annotation
A, B ABC transporter, permease proteinsearch ABC transporter, vitamin B12 import, permease protein BtuCsearch ABC transporter, BtuC-likesearch
C, D ABC transporter-likesearch AAA+ ATPase domainsearch ABC transporter, conserved sitesearch ABC transporter, vitamin B12, BtuDsearch P-loop containing nucleoside triphosphate hydrolasesearch