1l7v Summary

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Bacterial ABC Transporter Involved in B12 Uptake

The structure was published by Locher, K.P., Lee, A.T., and Rees, D.C., in 2002 in a paper entitled "The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely VITAMIN B12 TRANSPORT SYSTEM PERMEASE PROTEIN BTUC and Vitamin B12 transport ATP-binding protein btuD.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A VITAMIN B12 TRANSPORT SYSTEM PERMEASE PROTEIN BTUC P06609 (1-326) (BTUC_ECOLI)search Escherichia coli K-12search 100% 326 99%
B VITAMIN B12 TRANSPORT SYSTEM PERMEASE PROTEIN BTUC P06609 (1-326) (BTUC_ECOLI)search Escherichia coli K-12search 100% 326 99%
C Vitamin B12 transport ATP-binding protein btuD P06611 (1-249) (BTUD_ECOLI)search Escherichia coli K-12search 100% 249 92%
D Vitamin B12 transport ATP-binding protein btuD P06611 (1-249) (BTUD_ECOLI)search Escherichia coli K-12search 100% 249 92%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P06609 (1 - 326) VITAMIN B12 TRANSPORT SYSTEM PERMEASE PROTEIN BTUC Escherichia coli
P06611 (1 - 249) Vitamin B12 transport ATP-binding protein btuD Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P06609) ABC transporter involved in vitamin B12 uptake, BtuCsearch ABC transporter involved in vitamin B12 uptake, BtuCsearch PF01032: FecCD transport familysearch
C, D (P06611) ABC transporter ATPase domain-likesearch P-loop containing nucleotide triphosphate hydrolasessearch PF00005: ABC transportersearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P06609) transporter activitysearch protein bindingsearch cobalamin transporter activitysearch cobalamin-transporting ATPase activitysearch cobalamin transportsearch vitamin transmembrane transportsearch transportsearch membranesearch integral component of plasma membranesearch plasma membranesearch integral component of membranesearch ATP-binding cassette (ABC) transporter complexsearch
C, D (P06611) ATP bindingsearch ATPase activitysearch hydrolase activitysearch nucleotide bindingsearch cobalamin-transporting ATPase activitysearch protein bindingsearch cobalamin transportsearch ATP catabolic processsearch metabolic processsearch vitamin transmembrane transportsearch transportsearch plasma membranesearch cytosolsearch extrinsic component of membranesearch extrinsic component of cytoplasmic side of plasma membranesearch ATP-binding cassette (ABC) transporter complexsearch membranesearch

Chain InterPro annotation
A, B ABC transporter, permease proteinsearch ABC transporter, vitamin B12 import, permease protein BtuCsearch ABC transporter, BtuC-likesearch
C, D ABC transporter-likesearch AAA+ ATPase domainsearch ABC transporter, conserved sitesearch ABC transporter, vitamin B12, BtuDsearch P-loop containing nucleoside triphosphate hydrolasesearch