1l7q Summary

pdbe.org/1l7q
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Ser117Ala Mutant of Bacterial Cocaine Esterase cocE

The structure was published by Turner, J.M., Larsen, N.A., Basran, A., et al., Bruce, N.C., Wilson, I.A., and Lerner, R.A., in 2002 in a paper entitled "Biochemical characterization and structural analysis of a highly proficient cocaine esterase" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.76 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of cocaine esterase. This molecule has the UniProt identifier Q9L9D7 (COCE_RHOSM)search. The sample contained 574 residues which is 100% of the natural sequence. Out of 574 residues 570 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A cocaine esterase Q9L9D7 (1-574) (COCE_RHOSM)search Rhodococcus sp. MB1 'Bresler 1999'search 99% 574 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9L9D7 (1 - 574) cocaine esterase Rhodococcus sp. MB1

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q9L9D7) PepX C-terminal domain-likesearch, PepX catalytic domain-likesearch Rossmann foldsearch, Galactose-binding domain-likesearch, alpha-amino acid ester hydrolase ( Helical cap domain)search PF02129: X-Pro dipeptidyl-peptidase (S15 family)search, PF08530: X-Pro dipeptidyl-peptidase C-terminal non-catalytic domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q9L9D7) hydrolase activitysearch carboxylic ester hydrolase activitysearch dipeptidyl-peptidase activitysearch cytoplasmsearch cocaine catabolic processsearch proteolysissearch

Chain InterPro annotation
A Xaa-Pro dipeptidyl-peptidase-like domainsearch CocE/Serine esterasesearch Galactose-binding domain-likesearch Xaa-Pro dipeptidyl-peptidase, C-terminalsearch Alpha/Beta hydrolase foldsearch