1l7h Summary


Crystal structure of R292K mutant influenza virus neuraminidase in complex with BCX-1812

The structure was published by Smith, B.J., McKimm-Breshkin, J.L., McDonald, M., Fernley, R.T., Varghese, J.N., and Colman, P.M., in 2002 in a paper entitled "Structural studies of the resistance of influenza virus neuramindase to inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of neuraminidase. This molecule has the UniProt identifier P03472 (NRAM_I75A5)search. The sample contained 388 residues which is < 90% of the natural sequence. Out of 388 residues 388 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A neuraminidase P03472 (83-470) (NRAM_I75A5)search Influenza A virus (A/tern/Australia/G70C/1975(H11N9))search < 90% 388 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P03472 (83 - 470) neuraminidase Influenza A virus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Sialidases (neuraminidases)search Neuraminidasesearch Neuraminidasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P03472) host cell membranesearch virion membranesearch membranesearch exo-alpha-sialidase activitysearch carbohydrate metabolic processsearch

Chain InterPro annotation
A Glycoside hydrolase, family 34search Sialidasessearch