Human Estrogen Receptor alpha Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol and a Glucocorticoid Receptor Interacting Protein 1 NR box II Peptide
The structure was published by Shiau, A.K., Barstad, D., Radek, J.T., et al., Katzenellenbogen, J.A., Agard, D.A., and Greene, G.L., in 2002 in a paper entitled "Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2002.
The experimental data on which the structure is based was also deposited.
This PDB entry contains a complex of 2 biomacromolecules, namely ESTROGEN RECEPTOR and GLUCOCORTICOID RECEPTOR-INTERACTING PROTEIN 1.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 2 unique UniProt proteins: