1l2i Summary


Human Estrogen Receptor alpha Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol and a Glucocorticoid Receptor Interacting Protein 1 NR box II Peptide

The structure was published by Shiau, A.K., Barstad, D., Radek, J.T., et al., Katzenellenbogen, J.A., Agard, D.A., and Greene, G.L., in 2002 in a paper entitled "Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely ESTROGEN RECEPTOR and GLUCOCORTICOID RECEPTOR-INTERACTING PROTEIN 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ESTROGEN RECEPTOR P03372 (297-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 261 89%
B ESTROGEN RECEPTOR P03372 (297-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 261 89%
C GLUCOCORTICOID RECEPTOR-INTERACTING PROTEIN 1 Q61026 (686-698) (NCOA2_MOUSE)search Mus musculussearch < 90% 13 76%
D GLUCOCORTICOID RECEPTOR-INTERACTING PROTEIN 1 Q61026 (686-698) (NCOA2_MOUSE)search Mus musculussearch < 90% 13 76%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P03372 (297 - 554) ESTROGEN RECEPTOR Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch, Oestrogen-type nuclear receptor final C-terminalsearch
C, D Steroid receptor coactivatorsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P03372) nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D Nuclear receptor coactivator Src-1search