1l1r Summary


Crystal Structure of APRTase from Giardia lamblia Complexed with 9-deazaadenine, Mg2+ and PRPP

The structure was published by Shi, W., Sarver, A.E., Wang, C.C., Tanaka, K.S., Almo, S.C., and Schramm, V.L., in 2002 in a paper entitled "Closed Site Complexes of Adenine Phosphoribosyltransferase from Giardia lamblia Reveal a Mechanism of Ribosyl Migration." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Adenine phosphoribosyltransferase. This molecule has the UniProt identifier Q967M2 (Q967M2_GIAIN)search. The sample contained 186 residues which is 100% of the natural sequence. Out of 186 residues 177 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Adenine phosphoribosyltransferase Q967M2 (1-180) (Q967M2_GIAIN)search Giardia intestinalissearch 100% 186 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q967M2 (1 - 180) Adenine phosphoribosyltransferase Giardia intestinalis

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q967M2) Phosphoribosyltransferases (PRTases)search Rossmann foldsearch PF00156: Phosphoribosyl transferase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (Q967M2) nucleoside metabolic processsearch transferase activity, transferring glycosyl groupssearch transferase activitysearch

Chain InterPro annotation
A Phosphoribosyltransferase domainsearch Phosphoribosyltransferase-likesearch