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PDBe Entry: 1kzo 
PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYLATED K-RAS4B PEPTIDE PRODUCT AND FARNESYL DIPHOSPHATE SUBSTRATE BOUND SIMULTANEOUSLY
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TRANSFERASE
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X-RAY DIFFRACTION
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Resolution: 2.2 Å, R-factor: 16.2%, Free R-factor: 20.4%, Spacegroup: P 61
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16/10/2002, deposition: 07/02/2002, last revision: 24/02/2009
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Long, S.B.; Casey, P.J.; Beese, L.S.
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The Reaction Path of Protein Farnesyltransferase at Atomic Resolution
NATURE vol:419, pag:645-650 (2002) [PubMed ID 12374986 ]
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FTASE, PFT, PFTASE, FT, FPT, FARNESYLTRANSFERASE, FARNESYL TRANSFERASE, FARNESYL PROTEIN TRANSFERASE, CAAX, RAS, CANCER, PRODUCT, SUBSTRATE
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2.5.1.58 ExPASy BRENDA (A B), 2.5.1.59 ExPASy BRENDA (A)
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Rattus norvegicus(Norway rat) 10116(A B)
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Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (Ras proteins prenyltransferase alpha) (FTase-alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) Q04631 (A)
Protein farnesyltransferase subunit beta (EC 2.5.1.58) (FTase-beta) (CAAX farnesyltransferase subunit beta) (RAS proteins prenyltransferase beta) Q02293 (B)
GTPase KRas precursor (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) P01116 (C)
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A, B, C
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1kzp, 1d8d, 1ft1, 1ft2, 1kzr, 1jcq
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| A |
Protein Farnesyltransferase alpha subunit |
Protein |
Q04631 (FNTA_RAT)
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377 |
85% |
| B |
Protein Farnesyltransferase beta subunit |
Protein |
Q02293 (FNTB_RAT)
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437 |
93% |
| C |
Farnesylated K-Ras4B peptide product |
Protein |
P01116 (RASK_HUMAN)
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11 |
54% |
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| B |
ZINC ION |
ZN
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| C |
FARNESYL |
FAR
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| B |
FARNESYL DIPHOSPHATE |
FPP
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| B |
ACETIC ACID |
ACY
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