1kxq Summary

pdbe.org/1kxq
spacer

Camelid VHH Domain in Complex with Porcine Pancreatic alpha-Amylase

The structure was published by Desmyter, A., Spinelli, S., Payan, F., et al., Wyns, L., Muyldermans, S., and Cambillau, C., in 2002 in a paper entitled "Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely alpha-amylase, pancreatic and antibody VHH fragment CABAMD9.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A alpha-amylase, pancreatic P00690 (16-511) (AMYP_PIG)search Sus scrofasearch 100% 496 100%
B alpha-amylase, pancreatic P00690 (16-511) (AMYP_PIG)search Sus scrofasearch 100% 496 100%
C alpha-amylase, pancreatic P00690 (16-511) (AMYP_PIG)search Sus scrofasearch 100% 496 100%
D alpha-amylase, pancreatic P00690 (16-511) (AMYP_PIG)search Sus scrofasearch 100% 496 100%
E antibody VHH fragment CABAMD9 Not available
Camelus dromedariussearch Not available 120 100%
F antibody VHH fragment CABAMD9 Not available
Camelus dromedariussearch Not available 120 100%
G antibody VHH fragment CABAMD9 Not available
Camelus dromedariussearch Not available 120 100%
H antibody VHH fragment CABAMD9 Not available
Camelus dromedariussearch Not available 120 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00690 (16 - 511) alpha-amylase, pancreatic Sus scrofa

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P00690) alpha-Amylases, C-terminal beta-sheet domainsearch, Amylase, catalytic domainsearch Glycosidasessearch, Golgi alpha-mannosidase IIsearch PF00128: Alpha amylase, catalytic domainsearch, PF02806: Alpha amylase, C-terminal all-beta domainsearch
E, F, G, H V set domains (antibody variable domain-like)search Immunoglobulinssearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (P00690) carbohydrate metabolic processsearch metabolic processsearch carbohydrate catabolic processsearch cation bindingsearch catalytic activitysearch alpha-amylase activitysearch metal ion bindingsearch hydrolase activity, acting on glycosyl bondssearch chloride ion bindingsearch calcium ion bindingsearch hydrolase activitysearch extracellular regionsearch extracellular spacesearch

Chain InterPro annotation
A, B, C, D Alpha amylasesearch Glycosyl hydrolase, family 13, catalytic domainsearch Alpha-amylase, C-terminal all betasearch Glycosyl hydrolase, family 13, subfamily, catalytic domainsearch Glycosyl hydrolase, family 13, all-betasearch Glycoside hydrolase, catalytic domainsearch Glycoside hydrolase, family 13search Glycoside hydrolase superfamilysearch
E, F, G, H Immunoglobulin V-set, subgroupsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch