1kxq Summary

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Camelid VHH Domain in Complex with Porcine Pancreatic alpha-Amylase

The structure was published by Desmyter, A., Spinelli, S., Payan, F., et al., Wyns, L., Muyldermans, S., and Cambillau, C., in 2002 in a paper entitled "Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely alpha-amylase, pancreatic and antibody VHH fragment CABAMD9.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A alpha-amylase, pancreatic P00690 (16-511) (AMYP_PIG)search Sus scrofasearch 100% 496 100%
B alpha-amylase, pancreatic P00690 (16-511) (AMYP_PIG)search Sus scrofasearch 100% 496 100%
C alpha-amylase, pancreatic P00690 (16-511) (AMYP_PIG)search Sus scrofasearch 100% 496 100%
D alpha-amylase, pancreatic P00690 (16-511) (AMYP_PIG)search Sus scrofasearch 100% 496 100%
E antibody VHH fragment CABAMD9 Not available
Camelus dromedariussearch Not available 120 100%
F antibody VHH fragment CABAMD9 Not available
Camelus dromedariussearch Not available 120 100%
G antibody VHH fragment CABAMD9 Not available
Camelus dromedariussearch Not available 120 100%
H antibody VHH fragment CABAMD9 Not available
Camelus dromedariussearch Not available 120 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00690 (16 - 511) alpha-amylase, pancreatic Sus scrofa

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P00690) alpha-Amylases, C-terminal beta-sheet domainsearch, Amylase, catalytic domainsearch Glycosidasessearch, Golgi alpha-mannosidase IIsearch PF00128: Alpha amylase, catalytic domainsearch, PF02806: Alpha amylase, C-terminal all-beta domainsearch
E, F, G, H V set domains (antibody variable domain-like)search Immunoglobulinssearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (P00690) alpha-amylase activitysearch cation bindingsearch catalytic activitysearch hydrolase activitysearch metal ion bindingsearch chloride ion bindingsearch hydrolase activity, acting on glycosyl bondssearch calcium ion bindingsearch carbohydrate metabolic processsearch metabolic processsearch carbohydrate catabolic processsearch extracellular spacesearch extracellular regionsearch

Chain InterPro annotation
A, B, C, D Alpha amylasesearch Glycosyl hydrolase, family 13, catalytic domainsearch Alpha-amylase, C-terminal all betasearch Glycosyl hydrolase, family 13, subfamily, catalytic domainsearch Glycosyl hydrolase, family 13, all-betasearch Glycoside hydrolase, catalytic domainsearch Glycoside hydrolase, family 13search Glycoside hydrolase, superfamilysearch
E, F, G, H Immunoglobulin V-set, subgroupsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch