1kwr Summary

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HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 0134-36

The structure was published by Gruneberg, S., Stubbs, M.T., and Klebe, G., in 2002 in a paper entitled "Successful virtual screening for novel inhibitors of human carbonic anhydrase: strategy and experimental confirmation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Carbonic anhydrase II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase II P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch protein bindingsearch metal ion bindingsearch extracellular vesicular exosomesearch plasma membranesearch cytosolsearch microvillussearch axonsearch cytoplasmsearch apical part of cellsearch membranesearch extracellular spacesearch basolateral plasma membranesearch myelin sheathsearch positive regulation of cellular pH reductionsearch positive regulation of osteoclast differentiationsearch angiotensin-activated signaling pathwaysearch bicarbonate transportsearch response to zinc ionsearch one-carbon metabolic processsearch regulation of chloride transportsearch response to estrogensearch response to pHsearch secretionsearch response to steroid hormonesearch regulation of anion transportsearch positive regulation of dipeptide transmembrane transportsearch regulation of intracellular pHsearch morphogenesis of an epitheliumsearch response to organic substancesearch kidney developmentsearch small molecule metabolic processsearch odontogenesis of dentin-containing toothsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of bone resorptionsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch