1kv6 Summary

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X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation

The structure was published by Greschik, H., Wurtz, J.-M., Sanglier, S., et al., van Dorsselaer, A., Moras, D., and Renaud, J.-P., in 2002 in a paper entitled "Structural and Functional Evidence for Ligand-Independent Transcriptional Activation by the Estrogen-Related Receptor 3" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2002.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely ESTROGEN-RELATED RECEPTOR GAMMA and steroid receptor coactivator 1.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ESTROGEN-RELATED RECEPTOR GAMMA P62508 (229-458) (ERR3_HUMAN)search Homo sapienssearch < 90% 230 96%
B ESTROGEN-RELATED RECEPTOR GAMMA P62508 (229-458) (ERR3_HUMAN)search Homo sapienssearch < 90% 230 96%
C steroid receptor coactivator 1 Q15788 (686-700) (NCOA1_HUMAN)search Homo sapienssearch < 90% 15 73%
D steroid receptor coactivator 1 Q15788 (686-700) (NCOA1_HUMAN)search Homo sapienssearch < 90% 15 73%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62508 (229 - 458) ESTROGEN-RELATED RECEPTOR GAMMA Homo sapiens
Q15788 (686 - 700) steroid receptor coactivator 1

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
C, D Steroid receptor coactivatorsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P62508) nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D Nuclear receptor coactivator Src-1search Epsin-like, N-terminalsearch Steroid receptor coactivatorsearch