1kv2 Summary


Human p38 MAP Kinase in Complex with BIRB 796

The structure was published by Pargellis, C., Tong, L., Churchill, L., et al., Moss, N., Pav, S., and Regan, J., in 2002 in a paper entitled "Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of p38 MAP kinase. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 323 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A p38 MAP kinase Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) p38 MAP kinase Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) protein phosphorylationsearch glucose metabolic processsearch platelet activationsearch chondrocyte differentiationsearch MyD88-independent toll-like receptor signaling pathwaysearch positive regulation of myoblast differentiationsearch cellular response to vascular endothelial growth factor stimulussearch cellular response to lipopolysaccharidesearch positive regulation of transcription from RNA polymerase II promotersearch intracellular signal transductionsearch cell morphogenesissearch blood coagulationsearch RNA metabolic processsearch regulation of transcription, DNA-templatedsearch osteoclast differentiationsearch chemotaxissearch toll-like receptor TLR1:TLR2 signaling pathwaysearch toll-like receptor signaling pathwaysearch peptidyl-serine phosphorylationsearch positive regulation of protein import into nucleussearch positive regulation of blood vessel endothelial cell migrationsearch stress-induced premature senescencesearch angiogenesissearch p38MAPK cascadesearch gene expressionsearch response to lipopolysaccharidesearch toll-like receptor 4 signaling pathwaysearch phosphorylationsearch positive regulation of myoblast fusionsearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of erythrocyte differentiationsearch apoptotic processsearch toll-like receptor 2 signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch cartilage condensationsearch signal transductionsearch fatty acid oxidationsearch muscle cell differentiationsearch signal transduction in response to DNA damagesearch regulation of sequence-specific DNA binding transcription factor activitysearch 3'-UTR-mediated mRNA stabilizationsearch cellular response to ionizing radiationsearch negative regulation of canonical Wnt signaling pathwaysearch striated muscle cell differentiationsearch toll-like receptor 5 signaling pathwaysearch transcription, DNA-templatedsearch response to muramyl dipeptidesearch mRNA metabolic processsearch regulation of transcription from RNA polymerase II promotersearch lipopolysaccharide-mediated signaling pathwaysearch myoblast differentiation involved in skeletal muscle regenerationsearch DNA damage checkpointsearch toll-like receptor 3 signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch neurotrophin TRK receptor signaling pathwaysearch cellular component movementsearch positive regulation of muscle cell differentiationsearch stress-activated MAPK cascadesearch cellular response to DNA damage stimulussearch toll-like receptor 9 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch activation of MAPK activitysearch positive regulation of myotube differentiationsearch cell surface receptor signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch skeletal muscle tissue developmentsearch Ras protein signal transductionsearch innate immune responsesearch toll-like receptor TLR6:TLR2 signaling pathwaysearch ATP bindingsearch MAP kinase activitysearch protein bindingsearch MAP kinase kinase activitysearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch NFAT protein bindingsearch kinase activitysearch transferase activitysearch spindle polesearch cytosolsearch nucleussearch nucleoplasmsearch cytoplasmsearch mitochondrionsearch extracellular vesicular exosomesearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch