1kv2 Summary


Human p38 MAP Kinase in Complex with BIRB 796

The structure was published by Pargellis, C., Tong, L., Churchill, L., et al., Moss, N., Pav, S., and Regan, J., in 2002 in a paper entitled "Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of p38 MAP kinase. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 323 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A p38 MAP kinase Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) p38 MAP kinase Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) protein kinase activitysearch MAP kinase activitysearch ATP bindingsearch protein bindingsearch nucleotide bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch kinase activitysearch MAP kinase kinase activitysearch transferase activitysearch NFAT protein bindingsearch protein phosphorylationsearch lipopolysaccharide-mediated signaling pathwaysearch toll-like receptor signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch Ras protein signal transductionsearch innate immune responsesearch negative regulation of canonical Wnt signaling pathwaysearch response to muramyl dipeptidesearch p38MAPK cascadesearch cell surface receptor signaling pathwaysearch positive regulation of myotube differentiationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch positive regulation of muscle cell differentiationsearch cellular response to DNA damage stimulussearch toll-like receptor 10 signaling pathwaysearch phosphorylationsearch stress-activated MAPK cascadesearch platelet activationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch regulation of transcription, DNA-templatedsearch cell morphogenesissearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch cellular response to lipopolysaccharidesearch osteoclast differentiationsearch chemotaxissearch chondrocyte differentiationsearch intracellular signal transductionsearch blood coagulationsearch RNA metabolic processsearch response to lipopolysaccharidesearch cartilage condensationsearch skeletal muscle tissue developmentsearch cellular response to vascular endothelial growth factor stimulussearch signal transduction in response to DNA damagesearch muscle cell differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch myoblast differentiation involved in skeletal muscle regenerationsearch regulation of transcription from RNA polymerase II promotersearch transcription, DNA-templatedsearch stress-induced premature senescencesearch gene expressionsearch glucose metabolic processsearch response to stresssearch toll-like receptor 2 signaling pathwaysearch positive regulation of myoblast differentiationsearch MyD88-dependent toll-like receptor signaling pathwaysearch positive regulation of myoblast fusionsearch vascular endothelial growth factor receptor signaling pathwaysearch positive regulation of protein import into nucleussearch signal transductionsearch peptidyl-serine phosphorylationsearch fatty acid oxidationsearch toll-like receptor 5 signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch angiogenesissearch DNA damage checkpointsearch striated muscle cell differentiationsearch toll-like receptor 3 signaling pathwaysearch positive regulation of erythrocyte differentiationsearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch cellular component movementsearch 3'-UTR-mediated mRNA stabilizationsearch cellular response to ionizing radiationsearch mRNA metabolic processsearch regulation of sequence-specific DNA binding transcription factor activitysearch apoptotic processsearch activation of MAPK activitysearch cytosolsearch nucleussearch nucleoplasmsearch cytoplasmsearch mitochondrionsearch cellsearch extracellular vesicular exosomesearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch