1kv2 Summary

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Human p38 MAP Kinase in Complex with BIRB 796

The structure was published by Pargellis, C., Tong, L., Churchill, L., et al., Moss, N., Pav, S., and Regan, J., in 2002 in a paper entitled "Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of p38 MAP kinase. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 323 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A p38 MAP kinase Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) p38 MAP kinase Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch MAP kinase activitysearch protein bindingsearch protein serine/threonine kinase activitysearch MAP kinase kinase activitysearch NFAT protein bindingsearch transferase activitysearch kinase activitysearch nucleotide bindingsearch protein phosphorylationsearch phosphorylationsearch angiogenesissearch platelet activationsearch intracellular signal transductionsearch cell morphogenesissearch cellular response to lipopolysaccharidesearch striated muscle cell differentiationsearch cellular response to DNA damage stimulussearch osteoclast differentiationsearch chemotaxissearch toll-like receptor TLR1:TLR2 signaling pathwaysearch response to muramyl dipeptidesearch toll-like receptor signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch apoptotic processsearch lipopolysaccharide-mediated signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch positive regulation of myoblast fusionsearch blood coagulationsearch RNA metabolic processsearch regulation of transcription, DNA-templatedsearch positive regulation of myotube differentiationsearch chondrocyte differentiationsearch muscle cell differentiationsearch negative regulation of canonical Wnt signaling pathwaysearch gene expressionsearch toll-like receptor 4 signaling pathwaysearch positive regulation of myoblast differentiationsearch stress-induced premature senescencesearch cartilage condensationsearch cellular response to vascular endothelial growth factor stimulussearch signal transduction in response to DNA damagesearch positive regulation of blood vessel endothelial cell migrationsearch signal transductionsearch peptidyl-serine phosphorylationsearch skeletal muscle tissue developmentsearch DNA damage checkpointsearch MyD88-dependent toll-like receptor signaling pathwaysearch positive regulation of protein import into nucleussearch vascular endothelial growth factor receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch neurotrophin TRK receptor signaling pathwaysearch cellular component movementsearch toll-like receptor 5 signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch cellular response to ionizing radiationsearch regulation of sequence-specific DNA binding transcription factor activitysearch toll-like receptor 3 signaling pathwaysearch mRNA metabolic processsearch glucose metabolic processsearch myoblast differentiation involved in skeletal muscle regenerationsearch regulation of transcription from RNA polymerase II promotersearch p38MAPK cascadesearch positive regulation of erythrocyte differentiationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch response to lipopolysaccharidesearch toll-like receptor 9 signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch activation of MAPK activitysearch transcription, DNA-templatedsearch stress-activated MAPK cascadesearch toll-like receptor 10 signaling pathwaysearch positive regulation of muscle cell differentiationsearch cell surface receptor signaling pathwaysearch fatty acid oxidationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch Ras protein signal transductionsearch innate immune responsesearch cytosolsearch cytoplasmsearch nucleoplasmsearch nucleussearch cellsearch mitochondrionsearch extracellular vesicular exosomesearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch