1kv1 Summary


p38 MAP Kinase in Complex with Inhibitor 1

The structure was published by Pargellis, C., Tong, L., Churchill, L., et al., Moss, N., Pav, S., and Regan, J., in 2002 in a paper entitled "Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of p38 MAP kinase. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 330 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A p38 MAP kinase Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) p38 MAP kinase Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein bindingsearch MAP kinase kinase activitysearch protein serine/threonine kinase activitysearch kinase activitysearch ATP bindingsearch NFAT protein bindingsearch nucleotide bindingsearch transferase activitysearch protein phosphorylationsearch activation of MAPK activitysearch stress-induced premature senescencesearch MyD88-dependent toll-like receptor signaling pathwaysearch cellular response to DNA damage stimulussearch osteoclast differentiationsearch cell surface receptor signaling pathwaysearch regulation of transcription, DNA-templatedsearch chondrocyte differentiationsearch DNA damage checkpointsearch toll-like receptor 5 signaling pathwaysearch response to stresssearch p38MAPK cascadesearch negative regulation of canonical Wnt signaling pathwaysearch Ras protein signal transductionsearch positive regulation of protein import into nucleussearch glucose metabolic processsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch blood coagulationsearch chemotaxissearch neurotrophin TRK receptor signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch response to muramyl dipeptidesearch cartilage condensationsearch positive regulation of reactive oxygen species metabolic processsearch MyD88-independent toll-like receptor signaling pathwaysearch apoptotic processsearch RNA metabolic processsearch TRIF-dependent toll-like receptor signaling pathwaysearch skeletal muscle tissue developmentsearch regulation of transcription from RNA polymerase II promotersearch 3'-UTR-mediated mRNA stabilizationsearch cellular component movementsearch toll-like receptor signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch platelet activationsearch transcription, DNA-templatedsearch muscle cell differentiationsearch mRNA metabolic processsearch positive regulation of myotube differentiationsearch positive regulation of blood vessel endothelial cell migrationsearch fatty acid oxidationsearch toll-like receptor 3 signaling pathwaysearch peptidyl-serine phosphorylationsearch toll-like receptor 10 signaling pathwaysearch positive regulation of myoblast fusionsearch gene expressionsearch toll-like receptor 2 signaling pathwaysearch phosphorylationsearch toll-like receptor 9 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch cell morphogenesissearch signal transductionsearch cellular response to lipopolysaccharidesearch innate immune responsesearch signal transduction in response to DNA damagesearch positive regulation of erythrocyte differentiationsearch myoblast differentiation involved in skeletal muscle regenerationsearch intracellular signal transductionsearch positive regulation of myoblast differentiationsearch regulation of sequence-specific DNA binding transcription factor activitysearch angiogenesissearch positive regulation of muscle cell differentiationsearch vascular endothelial growth factor receptor signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch response to lipopolysaccharidesearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch stress-activated MAPK cascadesearch striated muscle cell differentiationsearch cellular response to ionizing radiationsearch nucleoplasmsearch cytosolsearch nucleussearch spindle polesearch cytoplasmsearch mitochondrionsearch extracellular vesicular exosomesearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch