1kv1 Summary


p38 MAP Kinase in Complex with Inhibitor 1

The structure was published by Pargellis, C., Tong, L., Churchill, L., et al., Moss, N., Pav, S., and Regan, J., in 2002 in a paper entitled "Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2002.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of p38 MAP kinase. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 330 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A p38 MAP kinase Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) p38 MAP kinase Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) protein phosphorylationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch DNA damage checkpointsearch RNA metabolic processsearch TRIF-dependent toll-like receptor signaling pathwaysearch peptidyl-serine phosphorylationsearch positive regulation of myoblast fusionsearch MyD88-independent toll-like receptor signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch blood coagulationsearch positive regulation of transcription from RNA polymerase II promotersearch cellular response to vascular endothelial growth factor stimulussearch neurotrophin TRK receptor signaling pathwaysearch chemotaxissearch toll-like receptor 4 signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch toll-like receptor signaling pathwaysearch cellular component movementsearch mRNA metabolic processsearch angiogenesissearch platelet activationsearch apoptotic processsearch muscle cell differentiationsearch positive regulation of myotube differentiationsearch gene expressionsearch positive regulation of blood vessel endothelial cell migrationsearch cell morphogenesissearch regulation of transcription, DNA-templatedsearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch phosphorylationsearch skeletal muscle tissue developmentsearch toll-like receptor 9 signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch positive regulation of protein import into nucleussearch transcription, DNA-templatedsearch signal transductionsearch cellular response to lipopolysaccharidesearch regulation of sequence-specific DNA binding transcription factor activitysearch negative regulation of canonical Wnt signaling pathwaysearch innate immune responsesearch signal transduction in response to DNA damagesearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch response to muramyl dipeptidesearch positive regulation of muscle cell differentiationsearch osteoclast differentiationsearch response to lipopolysaccharidesearch glucose metabolic processsearch response to stresssearch cellular response to DNA damage stimulussearch stress-activated MAPK cascadesearch vascular endothelial growth factor receptor signaling pathwaysearch cartilage condensationsearch striated muscle cell differentiationsearch stress-induced premature senescencesearch cellular response to ionizing radiationsearch activation of MAPK activitysearch lipopolysaccharide-mediated signaling pathwaysearch positive regulation of myoblast differentiationsearch intracellular signal transductionsearch fatty acid oxidationsearch cell surface receptor signaling pathwaysearch Ras protein signal transductionsearch p38MAPK cascadesearch myoblast differentiation involved in skeletal muscle regenerationsearch positive regulation of erythrocyte differentiationsearch toll-like receptor 5 signaling pathwaysearch chondrocyte differentiationsearch ATP bindingsearch protein kinase activitysearch protein bindingsearch kinase activitysearch MAP kinase activitysearch NFAT protein bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch MAP kinase kinase activitysearch nucleotide bindingsearch cytosolsearch nucleussearch cytoplasmsearch extracellular vesicular exosomesearch nucleoplasmsearch cellsearch mitochondrionsearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch