› 1kt0

X-ray diffraction
2.7Å resolution

Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes

Released:
DOI: 10.2210/pdb1kt0/pdb
PDB entry 1kt0 coloured by chain, front view.
PDB entry 1kt0 coloured by chain, side view.
PDB entry 1kt0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes.
Sinars CR, Cheung-Flynn J, Rimerman RA, Scammell JG, Smith DF, Clardy J
Proc Natl Acad Sci U S A 100 868-73 (2003)
PMID: 12538866

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-171693 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase FKBP5 Chain: A
Molecule details ›
Chain: A
Length: 457 amino acids
Theoretical weight: 51.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q13451 (Residues: 1-457; Coverage: 100%)
Gene names: AIG6, FKBP5, FKBP51
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: P3221
Unit cell:
a: 87.583Å b: 87.583Å c: 132.033Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.284 0.284 0.375
Expression system: Escherichia coli BL21

Quick links

Citations

38 review citations

Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement.
Pratt et al. (2004)
37 more

19 mentions without citation

FKBP51 and FKBP52 in signaling and disease.
Storer et al. (2011)
18 more