1koa Summary



The structure was published by Kobe, B., Heierhorst, J., Feil, S.C., et al., Benian, G.M., Weiss, K.R., and Kemp, B.E., in 1996 in a paper entitled "Giant protein kinases: domain interactions and structural basis of autoregulation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.3 Å and deposited in 1996.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of TWITCHIN. This molecule has the UniProt identifier Q23551 (UNC22_CAEEL)search. The sample contained 491 residues which is < 90% of the natural sequence. Out of 491 residues 447 were observed and are deposited in the PDB.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TWITCHIN Q23551 (6209-6699) (UNC22_CAEEL)search Caenorhabditis eleganssearch < 90% 491 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q23551 (6209 - 6699) TWITCHIN Caenorhabditis elegans

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A I set domainssearch, Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search, Immunoglobulinssearch Protein kinase domainsearch, Immunoglobulin I-set domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q23551) protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Immunoglobulin subtype 2search Immunoglobulin-like domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Immunoglobulin I-setsearch Immunoglobulin-like foldsearch Protein kinase, ATP binding sitesearch