1klu Summary

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Crystal structure of HLA-DR1/TPI(23-37) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)

The structure was published by Sundberg, E.J., Sawicki, M.W., Southwood, S., Andersen, P.S., Sette, A., and Mariuzza, R.A., in 2002 in a paper entitled "Minor structural changes in a mutated human melanoma antigen correspond to dramatically enhanced stimulation of a CD4+ tumor-infiltrating lymphocyte line." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.93 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This entry contains 8 copies of 4 unique biopolymers (complete list).

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN P01903 (29-207) (DRA_HUMAN)search Homo sapienssearch < 90% 179 100%
B HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-1 BETA CHAIN P04229 (30-219) (2B11_HUMAN)search Homo sapienssearch < 90% 190 100%
C Triosephosphate isomerase peptide P60174 (60-74) (TPIS_HUMAN)search Homo sapienssearch < 90% 15 100%
D ENTEROTOXIN TYPE C-3 P0A0L5 (28-266) (ENTC3_STAAU)search Staphylococcus aureussearch 99% 239 96%


This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P01903 (29 - 207) HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN Homo sapiens
P04229 (30 - 219) HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-1 BETA CHAIN Homo sapiens
P60174 (60 - 74) Triosephosphate isomerase peptide
P0A0L5 (28 - 266) ENTEROTOXIN TYPE C-3 Staphylococcus aureus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B C1 set domains (antibody constant domain-like)search, MHC antigen-recognition domainsearch Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
C Triosephosphate isomerasesearch
D (P0A0L5) Superantigen toxins, N-terminal domainsearch, Superantigen toxins, C-terminal domainsearch OB fold (Dihydrolipoamide Acetyltransferase, E2P)search, Ubiquitin-like (UB roll)search PF01123: Staphylococcal/Streptococcal toxin, OB-fold domainsearch, PF02876: Staphylococcal/Streptococcal toxin, beta-grasp domainsearch

Chain ID Biological process (GO) Cellular component (GO)
A (P01903) immune responsesearch antigen processing and presentationsearch membranesearch MHC class II protein complexsearch
B (P04229) antigen processing and presentationsearch immune responsesearch membranesearch MHC class II protein complexsearch
D (P0A0L5) pathogenesissearch extracellular regionsearch

Chain InterPro annotation
A MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
C
D Staphylococcal/Streptococcal toxin, beta-grasp domainsearch Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved sitesearch Staphylococcal/Streptococcal toxin, OB-foldsearch Staphylococcal/streptococcal toxin, bacterialsearch Enterotoxinsearch Superantigen, staphylococcal/streptococcal toxin, bacterialsearch Superantigen toxin, C-terminalsearch