1kkq Summary

pdbe.org/1kkq
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Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif

The structure was published by Xu, H.E., Stanley, T.B., Montana, V.G., et al., Kliewer, S.A., Willson, T.M., and Stimmel, J.B., in 2002 in a paper entitled "Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR and NUCLEAR RECEPTOR CO-REPRESSOR 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR Q07869 (200-468) (PPARA_HUMAN)search Homo sapienssearch < 90% 269 100%
B PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR Q07869 (200-468) (PPARA_HUMAN)search Homo sapienssearch < 90% 269 100%
C PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR Q07869 (200-468) (PPARA_HUMAN)search Homo sapienssearch < 90% 269 100%
D PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR Q07869 (200-468) (PPARA_HUMAN)search Homo sapienssearch < 90% 269 100%
E NUCLEAR RECEPTOR CO-REPRESSOR 2 Q9Y618 (2347-2365) (NCOR2_HUMAN)search Homo sapienssearch < 90% 19 100%
F NUCLEAR RECEPTOR CO-REPRESSOR 2 Q9Y618 (2347-2365) (NCOR2_HUMAN)search Homo sapienssearch < 90% 19 100%
G NUCLEAR RECEPTOR CO-REPRESSOR 2 Q9Y618 (2347-2365) (NCOR2_HUMAN)search Homo sapienssearch < 90% 19 100%
H NUCLEAR RECEPTOR CO-REPRESSOR 2 Q9Y618 (2347-2365) (NCOR2_HUMAN)search Homo sapienssearch < 90% 19 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q07869 (200 - 468) PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR Homo sapiens
Q9Y618 (2347 - 2365) NUCLEAR RECEPTOR CO-REPRESSOR 2

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
E, F, G, H

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B, C, D (Q07869) nucleussearch DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B, C, D Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Peroxisome proliferator-activated receptor, alphasearch Nuclear hormone receptor, ligand-bindingsearch
E, F, G, H