Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif
The structure was published by Xu, H.E., Stanley, T.B., Montana, V.G., et al., Kliewer, S.A., Willson, T.M., and Stimmel, J.B., in 2002 in a paper entitled "Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha." (abstract).
This crystal structure
was determined using
at a resolution of 3.0 Å and deposited in 2001.
The experimental data on which the structure is based was not deposited.
This PDB entry contains a complex of 2 biomacromolecules, namely PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR and NUCLEAR RECEPTOR CO-REPRESSOR 2.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.