1kkl Summary

pdbe.org/1kkl
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L.casei HprK/P in complex with B.subtilis HPr

The structure was published by Fieulaine, S., Morera, S., Poncet, S., et al., Janin, J., Deutscher, J., and Nessler, S., in 2002 in a paper entitled "X-ray structure of a bifunctional protein kinase in complex with its protein substrate HPr." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HprK protein and PHOSPHOCARRIER PROTEIN HPR.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The most likely quaternary structure is a 12meric assembly.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HprK protein Q9RE09 (128-319) (HPRK_LACCA)search Lactobacillus caseisearch < 90% 205 81%
B HprK protein Q9RE09 (128-319) (HPRK_LACCA)search Lactobacillus caseisearch < 90% 205 81%
C HprK protein Q9RE09 (128-319) (HPRK_LACCA)search Lactobacillus caseisearch < 90% 205 81%
H PHOSPHOCARRIER PROTEIN HPR P08877 (1-88) (PTHP_BACSU)search Bacillus subtilis subsp. subtilis str. 168search 99% 100 88%
I PHOSPHOCARRIER PROTEIN HPR P08877 (1-88) (PTHP_BACSU)search Bacillus subtilis subsp. subtilis str. 168search 99% 100 88%
J PHOSPHOCARRIER PROTEIN HPR P08877 (1-88) (PTHP_BACSU)search Bacillus subtilis subsp. subtilis str. 168search 99% 100 88%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q9RE09 (128 - 319) HprK protein Lactobacillus casei
P08877 (1 - 88) PHOSPHOCARRIER PROTEIN HPR Bacillus subtilis

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C HPr kinase HprK C-terminal domainsearch P-loop containing nucleotide triphosphate hydrolasessearch HPr Serine kinase N terminussearch, HPr Serine kinase C-terminal domainsearch
H, I, J (P08877) HPr-likesearch Histidine-containing Protein; Chain: A;search PF00381: PTS HPr component phosphorylation sitesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C (Q9RE09) ATP bindingsearch phosphorelay sensor kinase activitysearch protein kinase activitysearch regulation of carbohydrate metabolic processsearch phosphorelay signal transduction systemsearch
H, I, J (P08877) protein bindingsearch kinase activitysearch protein serine/threonine kinase activitysearch transferase activitysearch transcription, DNA-templatedsearch carbohydrate transportsearch phosphoenolpyruvate-dependent sugar phosphotransferase systemsearch transportsearch regulation of carbohydrate utilizationsearch protein phosphorylationsearch phosphorylationsearch regulation of transcription, DNA-templatedsearch cytoplasmsearch

Chain InterPro annotation
A, B, C HPr(Ser) kinase/phosphorylasesearch HPr kinase/phosphorylase, C-terminalsearch P-loop containing nucleoside triphosphate hydrolasesearch
H, I, J Phosphocarrier HPr protein-likesearch Phosphotransferase system, HPr histidine phosphorylation sitesearch Phosphotransferase system, HPr serine phosphorylation sitesearch