1kk8 Summary

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SCALLOP MYOSIN (S1-ADP-BeFx) IN THE ACTIN-DETACHED CONFORMATION

The structure was published by Himmel, D.M., Gourinath, S., Reshetnikova, L., Shen, Y., Szent-Gyorgyi, A.G., and Cohen, C., in 2002 in a paper entitled "Crystallographic findings on the internally uncoupled and near-rigor states of myosin: further insights into the mechanics of the motor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Myosin Heavy Chain, Striated muscle, Myosin Regulatory Light Chain, Striated adductor muscle, and Myosin Essential Light Chain,Striated adductor muscle.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Myosin Heavy Chain, Striated muscle P24733 (1-837) (MYS_ARGIR)search Argopecten irradianssearch < 90% 837 94%
B Myosin Regulatory Light Chain, Striated adductor muscle P13543 (14-152) (MLR_ARGIR)search Argopecten irradianssearch 92% 139 100%
C Myosin Essential Light Chain,Striated adductor muscle P07291 (2-155) (MLE_ARGIR)search Argopecten irradianssearch 95% 154 100%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P24733 (1 - 837) Myosin Heavy Chain, Striated muscle Argopecten irradians,
P13543 (14 - 152) Myosin Regulatory Light Chain, Striated adductor muscle Argopecten irradians
P07291 (2 - 155) Myosin Essential Light Chain,Striated adductor muscle Argopecten irradians

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Myosin S1 fragment, N-terminal domainsearch, Motor proteinssearch Myosin head (motor domain)search, IQ calmodulin-binding motifsearch, Myosin N-terminal SH3-like domainsearch
B (P13543) Calmodulin-likesearch EF-handsearch PF00036: EF handsearch
C (P07291) Calmodulin-likesearch EF-handsearch

Chain ID Molecular function (GO) Cellular component (GO)
A (P24733) motor activitysearch ATP bindingsearch myosin complexsearch
B (P13543) calcium ion bindingsearch
C (P07291) calcium ion bindingsearch myosin complexsearch

Chain InterPro annotation
A IQ motif, EF-hand binding sitesearch Myosin head, motor domainsearch Myosin, N-terminal, SH3-likesearch Myosin-like IQ motif-containing domainsearch P-loop containing nucleoside triphosphate hydrolasesearch
B EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
C EF-hand domainsearch EF-hand domain pairsearch