1kgs Citations

Evidence of intradomain and interdomain flexibility in an OmpR/PhoB homolog from Thermotoga maritima.

Structure 10 153-64 (2002)
Cited: 76 times
EuropePMC logo PMID: 11839301

Abstract

Two-component systems, the predominant signal transduction strategy used by prokaryotes, involve phosphorelay from a sensor histidine kinase (HK) to an intracellular response regulator protein (RR) that typically acts as a transcription regulator. RRs are modular proteins, usually composed of a conserved regulatory domain, which functions as a phosphorylation-activated switch, and an attached DNA binding effector domain. The crystal structure of a Thermotoga maritima transcription factor, DrrD, has been determined at 1.5 A resolution, providing the first structural information for a full-length member of the OmpR/PhoB subfamily of RRs. A small interdomain interface occurs between alpha 5 of the regulatory domain and an antiparallel sheet of the effector domain. The lack of an extensive interface in the unphosphorylated protein distinguishes DrrD from other structurally characterized multidomain RRs and suggests a different mode of interdomain regulation.

Reviews - 1kgs mentioned but not cited (4)

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Articles - 1kgs mentioned but not cited (27)

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  23. A structural model of the E. coli PhoB dimer in the transcription initiation complex. Tung CS, McMahon BH. BMC Struct. Biol. 12 3 (2012)
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  25. Structure of the response regulator VicR DNA-binding domain. Trinh CH, Liu Y, Phillips SE, Phillips-Jones MK. Acta Crystallogr. D Biol. Crystallogr. 63 266-269 (2007)
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Reviews citing this publication (5)

  1. The two faces of Janus: virulence gene regulation by CovR/S in group A streptococci. Churchward G. Mol. Microbiol. 64 34-41 (2007)
  2. Regulation of transcription by eukaryotic-like serine-threonine kinases and phosphatases in Gram-positive bacterial pathogens. Wright DP, Ulijasz AT. Virulence 5 863-885 (2014)
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  5. The 3D Genome: From Structure to Function. Mohanta TK, Mishra AK, Al-Harrasi A. Int J Mol Sci 22 11585 (2021)

Articles citing this publication (40)

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  38. Epistatic Effect of Regulators to the Adaptive Growth of Escherichia coli. Miyake Y, Yamamoto K. Sci Rep 10 3661 (2020)
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  40. Withdrawn Infect Disord Drug Targets (2012)