› 1kg0

X-ray diffraction
2.65Å resolution

Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC class II Receptor HLA-DR1

Released:
DOI: 10.2210/pdb1kg0/pdb
PDB entry 1kg0 coloured by chain, front view.
PDB entry 1kg0 coloured by chain, side view.
PDB entry 1kg0 coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1.
Mullen MM, Haan KM, Longnecker R, Jardetzky TS
Mol Cell 9 375-85 (2002)
PMID: 11864610

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-135315 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chain: A
Molecule details ›
Chain: A
Length: 180 amino acids
Theoretical weight: 20.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01903 (Residues: 28-207; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DRB1 beta chain Chain: B
Molecule details ›
Chain: B
Length: 188 amino acids
Theoretical weight: 21.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01911 (Residues: 32-219; Coverage: 79%)
Gene name: HLA-DRB1
Sequence domains:
Structure domains:
Hemagglutinin HA1 chain Chain: D
Molecule details ›
Chain: D
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: P03437 (Residues: 322-334; Coverage: 2%)
Gene name: HA
Soluble gp42 Chain: C
Molecule details ›
Chain: C
Length: 136 amino acids
Theoretical weight: 15.63 KDa
Source organism: human gammaherpesvirus 4
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P03205 (Residues: 86-221; Coverage: 61%)
Gene name: BZLF2
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: P6322
Unit cell:
a: 170.4Å b: 170.4Å c: 101Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.221 0.221 0.247
Expression systems:
  • Escherichia coli
  • Not provided
  • Trichoplusia ni

Quick links

Citations

20 review citations

The C-type lectin-like domain superfamily.
Zelensky et al. (2005)
19 more

47 mentions without citation

Fusing structure and function: a structural view of the herpesvirus entry machinery.
Connolly et al. (2011)
46 more