spacer Crystal Structure of Lactococcus lactis Formamido-pyrimidine DNA Glycosylase (alias Fpg or MutM) Non Covalently Bound to an AP Site Containing DNA.
UniProt
Accession P42371search
Name FPG_LACLC
Keywords Hydrolase, Zinc-finger, DNA-binding, Glycosidase, Multifunctional enzyme, Metal-binding, 3D-structure, Lyase, Direct protein sequencing, DNA repair, DNA damage, Zinc
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Polymers A B
 
Enzyme nomenclature
EC number 3.2.2.23 ExPASy BRENDA search
Polymers A, B
Name DNA-formamidopyrimidine glycosylase
Comment May play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents. Also involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA.
EC number 4.2.99.18 ExPASy BRENDA search
Polymers B, A
Name DNA-(apurinic or apyrimidinic site) lyase
Comment 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
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