1ke8 Summary

pdbe.org/1ke8
spacer

CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE

The structure was published by Bramson, H.N., Corona, J., Davis, S.T., et al., Veal, J.M., Walker, D.H., and Kuyper, L.F., in 2001 in a paper entitled "Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 281 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P24941) protein phosphorylationsearch positive regulation of transcription, DNA-templatedsearch potassium ion transportsearch mitotic nuclear divisionsearch cell divisionsearch histone phosphorylationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch centrosome duplicationsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch meiotic nuclear divisionsearch G1/S transition of mitotic cell cyclesearch cellular response to DNA damage stimulussearch DNA replicationsearch G2/M transition of mitotic cell cyclesearch meiotic cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch positive regulation of DNA-dependent DNA replication initiationsearch cellular response to nitric oxidesearch positive regulation of cell proliferationsearch phosphorylationsearch regulation of gene silencingsearch cell cyclesearch blood coagulationsearch DNA repairsearch Ras protein signal transductionsearch mitotic cell cyclesearch mitotic G1 DNA damage checkpointsearch ATP bindingsearch protein bindingsearch transferase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch metal ion bindingsearch histone kinase activitysearch kinase activitysearch nucleoplasmsearch cytosolsearch X chromosomesearch cytoplasmsearch Cajal bodysearch nucleussearch endosomesearch cyclin-dependent protein kinase holoenzyme complexsearch cytoskeletonsearch transcription factor complexsearch microtubule organizing centersearch centrosomesearch Y chromosomesearch chromosome, telomeric regionsearch condensed chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch