1ke8 Summary

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CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE

The structure was published by Bramson, H.N., Corona, J., Davis, S.T., et al., Veal, J.M., Walker, D.H., and Kuyper, L.F., in 2001 in a paper entitled "Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CELL DIVISION PROTEIN KINASE 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 281 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CELL DIVISION PROTEIN KINASE 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) CELL DIVISION PROTEIN KINASE 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) ATP bindingsearch protein bindingsearch nucleotide bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch cyclin bindingsearch protein serine/threonine kinase activitysearch kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch histone kinase activitysearch metal ion bindingsearch transferase activitysearch protein phosphorylationsearch centrosome duplicationsearch meiotic nuclear divisionsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch DNA repairsearch G1/S transition of mitotic cell cyclesearch cell divisionsearch G2/M transition of mitotic cell cyclesearch DNA replicationsearch phosphorylationsearch regulation of gene silencingsearch mitotic nuclear divisionsearch positive regulation of cell proliferationsearch cell cyclesearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch cellular response to nitric oxidesearch positive regulation of DNA-dependent DNA replication initiationsearch mitotic G1 DNA damage checkpointsearch blood coagulationsearch histone phosphorylationsearch mitotic cell cyclesearch cellular response to DNA damage stimulussearch Ras protein signal transductionsearch potassium ion transportsearch positive regulation of transcription, DNA-templatedsearch nucleoplasmsearch Y chromosomesearch microtubule organizing centersearch transcription factor complexsearch nucleussearch X chromosomesearch cytosolsearch centrosomesearch endosomesearch Cajal bodysearch cyclin-dependent protein kinase holoenzyme complexsearch cytoplasmsearch cytoskeletonsearch chromosome, telomeric regionsearch condensed chromosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch