1ke6 Summary

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CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH N-METHYL-{4-[2-(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOLO[5,4-E]INDOL-8-YLIDENE)HYDRAZINO]PHENYL}METHANESULFONAMIDE

The structure was published by Bramson, H.N., Corona, J., Davis, S.T., et al., Veal, J.M., Walker, D.H., and Kuyper, L.F., in 2001 in a paper entitled "Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2001.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cell division protein kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 298 residues which is 100% of the natural sequence. Out of 298 residues 278 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cell division protein kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 298 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cell division protein kinase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P24941) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P24941) ATP bindingsearch protein kinase activitysearch protein bindingsearch histone kinase activitysearch cyclin-dependent protein serine/threonine kinase activitysearch kinase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch cyclin bindingsearch metal ion bindingsearch nucleoplasmsearch cytosolsearch cyclin-dependent protein kinase holoenzyme complexsearch cytoplasmsearch microtubule organizing centersearch transcription factor complexsearch condensed chromosomesearch nucleussearch centrosomesearch endosomesearch Y chromosomesearch X chromosomesearch cytoskeletonsearch chromosome, telomeric regionsearch Cajal bodysearch positive regulation of cell proliferationsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch protein phosphorylationsearch mitotic G1 DNA damage checkpointsearch mitotic cell cyclesearch cellular response to DNA damage stimulussearch G2/M transition of mitotic cell cyclesearch DNA repairsearch regulation of gene silencingsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch histone phosphorylationsearch centrosome duplicationsearch DNA replicationsearch cellular response to nitric oxidesearch potassium ion transportsearch phosphorylationsearch cell divisionsearch meiotic nuclear divisionsearch cell cyclesearch blood coagulationsearch Ras protein signal transductionsearch G1/S transition of mitotic cell cyclesearch positive regulation of transcription, DNA-templatedsearch positive regulation of DNA-dependent DNA replication initiationsearch mitotic nuclear divisionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch