› 1kcw

X-ray diffraction
3Å resolution

X-RAY CRYSTAL STRUCTURE OF HUMAN CERULOPLASMIN AT 3.0 ANGSTROMS

Released:
DOI: 10.2210/pdb1kcw/pdb
PDB entry 1kcw coloured by chain, front view.
PDB entry 1kcw coloured by chain, side view.
PDB entry 1kcw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The X-ray structure of human serum ceruloplasmin at 3.1 angstrom: Nature of the copper centres.
Zaitseva I, Zaitsev V, Card G, Moshkov K, Bax B, Ralph A, Lindley P
J. Biol. Inorg. Chem. 1 15-23 (1996)

Function and Biology Details

Reaction catalysed: 
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132511 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ceruloplasmin Chain: A
Molecule details ›
Chain: A
Length: 1046 amino acids
Theoretical weight: 120.23 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00450 (Residues: 20-1065; Coverage: 100%)
Gene name: CP
Sequence domains:
Structure domains: Cupredoxins - blue copper proteins

Ligands and Environments

3 bound ligands:
Ligand NAG 2 x NAG
Ligand CU 8 x CU
Ligand O 2 x O
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P3221
Unit cell:
a: 213.92Å b: 213.92Å c: 85.63Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.22 0.286

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Citations

17 mentions without citation

Multi-copper oxidases and human iron metabolism.
Vashchenko et al. (2013)
16 more