1kc2 Summary

pdbe.org/1kc2
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structure of the triple (Lys(beta)D3Ala, Asp(beta)C8Ala, AspCD2Ala) mutant of the Src SH2 domain bound to the PQpYEEIPI peptide

The structure was published by Lubman, O.Y. and Waksman, G., in 2002 in a paper entitled "Dissection of the energetic coupling across the Src SH2 domain-tyrosyl phosphopeptide interface." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2001.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Src Tyrosine kinase and PQpYEEIPI peptide.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Src Tyrosine kinase P00524 (145-247) (SRC_RSVSA)search Rous sarcoma virus (strain Schmidt-Ruppin A)search < 90% 103 93%
B PQpYEEIPI peptide Not available
Synthetic Not available 8 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00524 (145 - 247) Src Tyrosine kinase Rous sarcoma virus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A SH2 domainsearch SHC Adaptor Proteinsearch SH2 domainsearch
B
Chain InterPro annotation
A SH2 domainsearch
B