1k4u Summary

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Solution structure of the C-terminal SH3 domain of p67phox complexed with the C-terminal tail region of p47phox

The structure was published by Kami, K., Takeya, R., Sumimoto, H., and Kohda, D., in 2002 in a paper entitled "Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p." (abstract).

The structure was determined using NMR spectroscopy and deposited in 2001.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely PHAGOCYTE NADPH OXIDASE SUBUNIT P67PHOX and PHAGOCYTE NADPH OXIDASE SUBUNIT P47PHOX.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
S PHAGOCYTE NADPH OXIDASE SUBUNIT P67PHOX P19878 (455-516) (NCF2_HUMAN)search Homo sapienssearch < 90% 62 100%
P PHAGOCYTE NADPH OXIDASE SUBUNIT P47PHOX P14598 (359-390) (NCF1_HUMAN)search Homo sapienssearch < 90% 32 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P19878 (455 - 516) PHAGOCYTE NADPH OXIDASE SUBUNIT P67PHOX Homo sapiens
P14598 (359 - 390) PHAGOCYTE NADPH OXIDASE SUBUNIT P47PHOX Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
S SH3-domainsearch SH3 Domainssearch SH3 domainsearch
P NADPH oxidase subunit p47Phox, C terminal domainsearch
Chain InterPro annotation
S SH3 domainsearch
P NADPH oxidase subunit p47Phox, C-terminalsearch