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Solution structure of the C-terminal SH3 domain of p67phox complexed with the C-terminal tail region of p47phox

Solution NMR
PDB entry 1k4u coloured by chain, ensemble of 22 models, front view.
PDB entry 1k4u coloured by chain, ensemble of 22 models, side view.
PDB entry 1k4u coloured by chain, ensemble of 22 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Neutrophil cytosol factor 1 and Neutrophil cytosol factor 2
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Multimeric state: hetero dimer
Accessible surface area: 6008.48 Å2
Buried surface area: 1558.77 Å2
Dissociation area: 779.38 Å2
Dissociation energy (ΔGdiss): 7.25 kcal/mol
Dissociation entropy (TΔSdiss): 9.44 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-146973

Macromolecules

Neutrophil cytosol factor 2
Chain: S
Length: 62 amino acids
Theoretical weight: 6.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19878 (Residues: 455-516; Coverage: 12%)
Gene names: NCF2, NOXA2, P67PHOX
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains
SCOP: SH3-domain
Neutrophil cytosol factor 2 in PDB entry 1k4u, assembly 1, front view.
Neutrophil cytosol factor 2 in PDB entry 1k4u, assembly 1, side view.
Neutrophil cytosol factor 2 in PDB entry 1k4u, assembly 1, top view.
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Neutrophil cytosol factor 1
Chain: P
Length: 32 amino acids
Theoretical weight: 3.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P14598 (Residues: 359-390; Coverage: 8%)
Gene names: NCF1, NOXO2, SH3PXD1A
Pfam: NADPH oxidase subunit p47Phox, C terminal domain
InterPro: Neutrophil cytosol factor 1, C-terminal
Neutrophil cytosol factor 1 in PDB entry 1k4u, assembly 1, front view.
Neutrophil cytosol factor 1 in PDB entry 1k4u, assembly 1, side view.
Neutrophil cytosol factor 1 in PDB entry 1k4u, assembly 1, top view.
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